Dependence of high altitude sleep apnea on ventilatory sensitivity to hypoxia

Respiration Physiology
S LahiriM G Sherpa

Abstract

Respiration in man exposed to 5400 m was studied during sleep over a period of 6-8 h at night. Subjects were adult males, and belonged to distinct groups: one was Sherpa high altitude residents of the Himalayas and the other consisted of causasian sojourners from near sea level. All the volunteers had spent at least 32 days at or above 5400 m before the study. The subjects were instrumented for the measurements of breath-by-breath ventilation, SaO2%, eye-movement and heart rate. Nasal prongs were secured for the administration of mixtures of O2, N2 or CO2. Also, ventilatory sensitivity to hypoxia was studied in the awake state by the transient N2 and O2 tests. The lowlanders who showed high respiratory sensitivity to hypoxia also manifested periodic breathing with apnea during sleep. A raised PIO2 and SaO2% decreased ventilation, raised PACO2, attenuated respiratory oscillations and eliminated apnea in the sojourners. CO2 inhalation in air also eliminated apnea but not the periodicity, indicating that respiratory alkalosis caused apnea but periodic breathing was independent of central stimulation by CO2-H+. None of the Sherpa highlanders with low ventilatory sensitivity to hypoxia showed any sustained periodic breathing with ap...Continue Reading

References

Feb 1, 1978·Chest·C Guilleminault
Dec 13, 1979·The New England Journal of Medicine·J R SuttonA C Powles
Sep 1, 1978·Respiration Physiology·S LahiriA P Fishman
Nov 1, 1978·Archives of Neurology·K Kuban
Apr 1, 1973·Respiration Physiology·N H EdelmanN S Cherniack
Dec 1, 1973·Respiration Physiology·M C BlayoJ J Pocidalo
Jan 1, 1971·The Journal of Clinical Investigation·J V WeilR F Grover
Feb 19, 1970·The New England Journal of Medicine·N H EdelmanA P Fishman
Jan 1, 1966·Respiration Physiology·J W SeveringhausA Carcelen
May 1, 1967·Respiration Physiology·J S Milledge, S Lahiri
May 1, 1967·Respiration Physiology·S Lahiri, J S Milledge
Mar 1, 1980·Respiration Physiology·F L Eldridge
Feb 18, 1982·Brain Research·S LahiriA Mokashi
Aug 6, 1981·The New England Journal of Medicine·N S Cherniack
Dec 1, 1981·The Journal of Pediatrics·E TabachnikH Levison
Jul 1, 1954·A.M.A. Archives of Neurology and Psychiatry·H E HOFF, C G BRECKENRIDGE

❮ Previous
Next ❯

Citations

Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·J H CooteB Stone
Sep 1, 1993·Annals of Biomedical Engineering·K B Saunders, J Stradling
Sep 1, 1993·Annals of Biomedical Engineering·S D Ghazanshahi, M C Khoo
Sep 1, 1993·Annals of Biomedical Engineering·A I Pack, A Gottschalk
Dec 4, 2009·Lung·Laila AlDabal, Ahmed S BaHammam
Mar 31, 2005·Neuropsychology Review·Javier Virués-OrtegaBernardino Alcázar
Mar 19, 2002·Sleep & Breathing = Schlaf & Atmung·Himanshu Wickramasinghe, James D. Anholm
Aug 1, 1989·Respiration Physiology·R B SantolayaR B Schoene
Oct 1, 1994·Respiration Physiology·C L Webb, W K Milsom
Jan 1, 1996·Respiration Physiology·M C KhooC S Houston
Jul 1, 1996·Respiration Physiology·M H WilkinsonC Jones
May 1, 1995·Pharmacology, Biochemistry, and Behavior·D MontiM Radulovacki
Sep 1, 2000·Respiration Physiology·M C Khoo
Jul 3, 2002·Respiratory Physiology & Neurobiology·Sukhamay LahiriArijit Roy
Oct 17, 1998·Respiration Physiology·G RodasJ L Ventura
Sep 17, 1988·Lancet·T C HarveyA R Bradwell
Feb 1, 1997·Emergency Medicine Clinics of North America·K Zafren, B Honigman
Oct 19, 2002·Respiratory Physiology & Neurobiology·Yasuhiro AraiTakayuki Kuriyama
Jun 18, 2003·Respiratory Physiology & Neurobiology·Kingman P Strohl
Jul 11, 2003·Respiratory Physiology & Neurobiology·Robert PływaczewskiJan Zieliński
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keith R BurgessJackie Cooper
Mar 21, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Gareth AndrewsKeith R Burgess
Jun 20, 1992·BMJ : British Medical Journal·I P Hall, A T Cole
Mar 1, 1987·Postgraduate Medical Journal·J S Milledge
Apr 9, 2011·Journal of Applied Physiology·Shamim NematiJames P Butler
Aug 1, 1993·The American Review of Respiratory Disease·M NaughtonT D Bradley
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Hideaki NakayamaJerome A Dempsey
Apr 17, 2012·Biomedical Engineering Online·Joon LeeAtul Malhotra
Dec 7, 2013·British Journal of Sports Medicine·Charli SargentGregory D Roach
Sep 16, 2014·Respiratory Physiology & Neurobiology·Fernando A MoragaJorge Osorio
Mar 22, 2001·High Altitude Medicine & Biology·S LahiriN S Cherniack
Jul 22, 2004·High Altitude Medicine & Biology·John V Weil
Sep 19, 2006·High Altitude Medicine & Biology·Tianyi Wu, Bengt Kayser
Jul 1, 2010·High Altitude Medicine & Biology·John B West
Jun 9, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keith R BurgessNatalie Edwards
May 18, 2013·Respiratory Physiology & Neurobiology·Maria PlatakiAtul Malhotra
Sep 3, 2005·Progress in Biophysics and Molecular Biology·S LahiriN R Prabhakar
Mar 18, 2017·High Altitude Medicine & Biology·Luu V PhamAlan R Schwartz
Mar 1, 2005·Respiratory Physiology & Neurobiology·Ri-Li GeT G Babb
Sep 10, 2014·Sleep·Keith R BurgessPhilip N Ainslie
Nov 1, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeremy E OrrScott A Sands
Sep 10, 2002·Depression and Anxiety·Walton T RothFrank H Wilhelm
Feb 2, 2018·Journal of Applied Physiology·Keith R BurgessPhilip N Ainslie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.