PMID: 16502658Mar 1, 2006Paper

Dependence of mechanical behavior of the murine tail disc on regional material properties: a parametric finite element study

Journal of Biomechanical Engineering
Adam H HsiehJeffrey C Lotz

Abstract

In vivo rodent tail models are becoming more widely used for exploring the role of mechanical loading on the initiation and progression of intervertebral disc degeneration. Historically, finite element models (FEMs) have been useful for predicting disc mechanics in humans. However, differences in geometry and tissue properties may limit the predictive utility of these models for rodent discs. Clearly, models that are specific for rodent tail discs and accurately simulate the disc's transient mechanical behavior would serve as important tools for clarifying disc mechanics in these animal models. An FEM was developed based on the structure, geometry, and scale of the mouse tail disc. Importantly, two sources of time-dependent mechanical behavior were incorporated: viscoelasticity of the matrix, and fluid permeation. In addition, a novel strain-dependent swelling pressure was implemented through the introduction of a dilatational stress in nuclear elements. The model was then validated against data from quasi-static tension-compression and compressive creep experiments performed previously using mouse tail discs. Finally, sensitivity analyses were performed in which material parameters of each disc subregion were individually vari...Continue Reading

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Citations

Jul 29, 2008·Biomechanics and Modeling in Mechanobiology·W EhlersB Markert
Mar 8, 2011·Biomechanics and Modeling in Mechanobiology·David HwangAdam H Hsieh
Aug 9, 2012·Biomechanics and Modeling in Mechanobiology·N KarajanS Schmitt
Aug 4, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Ali Vahdati, Diane R Wagner
Feb 21, 2014·Biomechanics and Modeling in Mechanobiology·N KarajanW Ehlers
May 26, 2012·The Spine Journal : Official Journal of the North American Spine Society·Arthur J Michalek, James C Iatridis
Jul 26, 2011·Journal of the Mechanical Behavior of Biomedical Materials·Nathaniel T Hollingsworth, Diane R Wagner
Oct 16, 2009·Journal of Biomechanics·Adam H Hsieh, Julianne D Twomey
Nov 28, 2015·Computer Methods in Biomechanics and Biomedical Engineering·Molly T Townsend, Nesrin Sarigul-Klijn
Dec 21, 2017·The American Journal of Hospice & Palliative Care·Erica V TartaglioneLynn F Reinke
Sep 23, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Semih E BezciGrace D O'Connell

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