Dependence of optimal seed bubble size on pressure amplitude at therapeutic pressure levels
Abstract
Medical ultrasound has shown great potential as a minimally invasive therapy technique. It can be used in areas such as histotripsy, thermal ablation, and administering medication. The success of these therapies is improved by the cavitation of small microbubbles, and often it is useful to know which bubbles might provide the most effective therapy. When using therapies based on stable cavitation, the optimal bubble size is approximately given by R(0)≅3MHzμm/f(0)(lin). However, a similar expression is not available for therapies involving inertial cavitation. Therefore, the goal of our study was to develop an approximate expression relating the initial size of the bubble that resulted in the maximum response to the ultrasound operating frequency and pressure of the ultrasound wave when inertial cavitation is expected. The study was conducted by simulating the response of air bubbles in water to linearly propagating sine waves using the Gilmore-Akulichev formulation to solve for the bubble response. The frequency of the sine wave varied from 0.5 to 5MHz while the amplitude of the sine wave varied from 0.0001 to 5MPa. The optimal initial size for a particular frequency of excitation and amplitude, which is normally only establish...Continue Reading
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Enhanced antitumor efficacy of ultrasonic cavitation with up-sized microbubbles in pancreatic cancer
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