Dependence of photocarcinogenesis and photoimmunosuppression in the hairless mouse on dietary polyunsaturated fat

Cancer Letters
V E ReeveC Boehm-Wilcox

Abstract

A series of semi-purified diets containing 20% fat by weight, of increasing proportions (0, 5%, 10%, 15% or 20%) of polyunsaturated sunflower oil mixed with hydrogenated saturated cottonseed oil, was fed to groups of Skh:HR-1 hairless mice during induction and promotion of photocarcinogenesis. The photocarcinogenic response was of increasing severity as the polyunsaturated content of the mixed dietary fat was increased, whether measured as tumour incidence, tumour multiplicity, progression of benign tumours to squamous cell carcinoma, or reduced survival. At the termination of the study approximately 6 months following the completion of the 10-week chronic UV irradiation treatment, when most mice bore tumours, the contact hypersensitivity (CHS) reactions in those groups supporting the highest tumour leads (fed 15% or 20% polyunsaturated fat), were significantly suppressed in comparison with the mice bearing smaller tumour loads (fed 0, 5% or 10% polyunsaturated fat). When mice were exposed acutely to UV radiation (UVR), a diet of 20% saturated fat provided almost complete protection from the suppression of CHS, whereas feeding 20% polyunsaturated fat resulted in 57% suppression; the CHS of unirradiated mice was unaffected by th...Continue Reading

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Citations

Oct 25, 2003·Toxicology and Applied Pharmacology·Juliette L LeeMohammad Athar
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Vivienne E Reeve
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·G LiuZ Dong
Feb 11, 2016·Journal of Clinical Medicine·Homer S Black, Lesley E Rhodes
Apr 20, 2000·Redox Report : Communications in Free Radical Research·D DomanskiV E Reeve
Dec 22, 2004·Environmental and Molecular Mutagenesis·Mar Rojas-MolinaAngeles Alonso-Moraga
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Maria Celia HughesAdèle C Green
May 17, 2011·Experimental Dermatology·Suzanne M PilkingtonLesley E Rhodes
Feb 1, 2013·The American Journal of Clinical Nutrition·Suzanne M PilkingtonLesley E Rhodes
Feb 27, 2009·The American Journal of Clinical Nutrition·Maria Celia B HughesAdèle C Green
Jul 26, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sarah C WallingfordJolieke C van der Pols
Oct 5, 2010·Journal of Agricultural and Food Chemistry·Smita SrivastavaYogeshwer Shukla

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