Dependence of phrenic motoneurone output on the oscillatory component of arterial blood gas composition

The Journal of Physiology
B A CrossR P Stidwill

Abstract

1. The hypothesis that respiratory oscillations of arterial blood gas composition influence ventilation has been examined. 2. Phrenic motoneurone output recorded in the C5 root of the left phrenic nerve and the respiratory oscillations of arterial pH in the right common carotid artery were measured in vagotomized anaesthetized dogs which had been paralysed and artificially ventilated. 3. The effect of a change in tidal volume for one or two breaths on phrenic motoneurone output was measured with the inspiratory pump set at a constant frequency similar to, and in phase with, the animal's own respiratory frequency. A reduction of tidal volume to zero or an increase by 30% led to a corresponding change of mean carotid artery pH level. The changes of carotid artery pH resulted in a change of phrenic motoneurone output, predominantly of expiratory time (Te) but to a lesser extent of inspiratory time (T1) and also peak amplitude of 'integrated' phrenic motoneurone output (Phr). Denervation of the carotid bifurcation blocked this response. 4. The onset of movement of the inspiratory pump was triggered by the onset of phrenic motoneurone output. When a time delay was interposed between them, the phase relationship between respiratory o...Continue Reading

Citations

Nov 26, 2003·Respiratory Physiology & Neurobiology·Tetsuri KondoBeverly Bishop
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Jan 1, 1984·Respiration Physiology·D TrenchardH E Raybould
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Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Anthony J RiceJerome A Dempsey
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Dec 24, 2002·Journal of Applied Physiology·Daniel L YoungChi-Sang Poon

Related Concepts

Nerve Impulses
Metazoa
Blood Gas Analysis
Carbon Dioxide
Carotid Arteries
Carotid Body
Denervation
Canis familiaris
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