Dependence of temporal variability of ventricular recovery on myocardial fibrosis. Role of mechanoelectric feedback?

Cardiovascular Research
D StilliE Musso

Abstract

The study was aimed at establishing the effect of factors involved in the expression of mechanoelectric feedback in the heart, such as R-R interval and connective tissue, on time dependent changes in ventricular recovery, as determined at the body surface by beat to beat variability of QRST integral maps (BBV-IM). We used 15 normal 6-month-old Wistar rats. In each anesthetized animal, we performed a 3-minute continuous recording of 44. The simultaneous chest ECGs. The signals were interactively processed, 1) to determine mean R-R interval and R-R variability throughout the recording period and 2) to compute QRST integral maps from approximately 50 beats belonging to the end of expiration. Then BBV-IM was calculated and expressed as percentage of beats significantly differing from a template. At sacrifice, the amount of myocardial fibrosis was morphometrically evaluated. R-R interval was 149 ms +/- 4, R-R interval variability 0.008 +/- 0.001 and BBV-IM 30.7% +/- 4.4. Myocardial fibrosis expressed as % volume of left ventricular myocardium, numerical density of fibrotic foci and average cross-sectional area of the foci was 3.0% +/- 0.4, 3.8 +/- 0.6 and 4.4 microns(2)/1000 +/- 0.1 respectively, BB-IM was positively correlated to t...Continue Reading

Citations

Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
Dec 10, 2014·Particle and Fibre Toxicology·Monia SaviMassimiliano Zaniboni
Sep 15, 2000·Cardiology Clinics·P KohlE White
Feb 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tania CostoliAndrea Sgoifo
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Dec 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Donatella BrisindaRiccardo Fenici
Nov 14, 1998·The American Journal of Physiology·E MacchiB Taccardi

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