Dependence of thresholds for pulmonary capillary hemorrhage on diagnostic ultrasound frequency

Ultrasound in Medicine & Biology
Douglas L MillerKrishnan Raghavendran

Abstract

Pulmonary ultrasound examination has become routine for diagnosis in many clinical and point-of-care medical settings. However, the phenomenon of pulmonary capillary hemorrhage (PCH) induction during diagnostic ultrasound imaging presents a poorly understood risk factor. PCH was observed in anesthetized rats exposed to 1.5-, 4.5- and 12.0-MHz diagnostic ultrasound to investigate the frequency dependence of PCH thresholds. PCH was detected in the ultrasound images as growing comet tail artifacts and was assessed using photographs of the surface of excised lungs. Previous photographs acquired after exposure to 7.6-MHz diagnostic ultrasound were included for analysis. In addition, at each frequency we measured dosimetric parameters, including peak rarefactional pressure amplitude and spatial peak, pulse average intensity attenuated by rat chest wall samples. Peak rarefactional pressure amplitude thresholds determined at each frequency, based on the proportion of PCH in groups of five rats, were 1.03 ± 0.02, 1.28 ± 0.14, 1.18 ± 0.12 and 1.36 ± 0.15 MPa at 1.5, 4.5, 7.6 and 12.0 MHz, respectively. Although the PCH lesions decreased in size with increasing ultrasonic frequency, owing to the smaller beam widths and scan lengths, the p...Continue Reading

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Citations

Jan 18, 2016·Ultrasound in Medicine & Biology·Douglas L MillerKrishnan Raghavendran
Apr 28, 2016·Ultrasound in Medicine & Biology·Douglas L MillerKrishnan Raghavendran
May 3, 2015·Ultrasound in Medicine & Biology·Douglas L MillerKrishnan Raghavendran
Feb 10, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerKrishnan Raghavendran
Feb 1, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerKrishnan Raghavendran
Aug 29, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerZhihong Dong
Nov 21, 2017·Journal of Therapeutic Ultrasound·Douglas L MillerOliver D Kripfgans

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