PMID: 2489061Feb 1, 1989Paper

Dependence on heparin chain-length of the interaction of heparin with human plasma low density lipoproteins

International Journal of Biological Macromolecules
A D CardinD Feldhake

Abstract

Successive rechromatography of commercial bovine lung heparin on human plasma low density lipoproteins (LDL) immobilized to AffiGel-10 yielded four high reactive heparin (HRH-I to IV) fractions and an unreactive fraction (URH). HRH-I was the most sulphated HRH fraction whereas URH had the least sulphation. In the presence of 10 mM Ca2+, LDL were precipitated by these heparins in the following order: HRH-II greater than HRH-III greater than HRH-IV greater than HRH-I greater than URH. The average molecular weight of HRH-I to IV was 8600, 11400, 10,100, and 10,000, respectively. A plot of log molecular weight versus the concentration of HRH required to give half-maximal precipitation of LDL showed a negative correlation (r = -0.880). These results indicate that heparin chain length is an important determinant of heparin binding to LDL in solution and may have relevance to the binding and precipitation of LDL in the arterial wall.

References

Aug 1, 1978·The Journal of Clinical Investigation·G S Omenn, L T Smith
Jul 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G CamejoG Bondjers
Jan 1, 1985·Advances in Carbohydrate Chemistry and Biochemistry·B Casu
Jun 1, 1971·Analytical Biochemistry·T T Terho, K Hartiala
Aug 1, 1973·Analytical Biochemistry·N Blumenkrantz, G Asboe-Hansen
Jul 1, 1973·Carbohydrate Research·A Linker, P Hovingh
Feb 1, 1970·Analytical Biochemistry·D R Harvey
Mar 1, 1984·Analytical Biochemistry·A D CardinR L Jackson
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR

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