Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response

Current Biology : CB
Young Kwon, C Montell

Abstract

The Drosophila phototransduction cascade serves as a paradigm for characterizing the regulation of sensory signaling and TRP channels in vivo . Activation of these channels requires phospholipase C (PLC) and may depend on subsequent production of diacylglycerol (DAG) and downstream metabolites . DAG could potentially be produced through a second pathway involving the combined activities of a phospholipase D (PLD) and a phosphatidic acid (PA) phosphatase (PAP). However, a role for a PAP in the regulation of TRP channels has not been described. Here, we report the identification of a PAP, referred to as Lazaro (Laza). Mutations in laza caused a reduction in the light response and faster termination kinetics. Loss of laza suppressed the severity of the phenotype caused by mutation of the DAG kinase, RDGA , indicating that Laza functions in opposition to RDGA. We also showed that the retinal degeneration resulting from overexpression of the PLD was suppressed by elimination of Laza. These data demonstrate a requirement for a PLD/PAP-dependent pathway for achieving the maximal light response. The genetic interactions with both rdgA and Pld indicate that Laza functions in the convergence of both PLC- and PLD-coupled signaling in vivo.

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Citations

May 10, 2007·Pflügers Archiv : European journal of physiology·Tao Wang, Craig Montell
Aug 2, 2011·Chemical Reviews·Yulia V ShulgaRichard M Epand
Mar 3, 2009·Molecular Biology and Evolution·Riyue Bao, Markus Friedrich
Jun 21, 2007·Annual Review of Biochemistry·Kartik Venkatachalam, Craig Montell
Oct 16, 2009·Journal of Lipid Research·Norma M GiustoMónica G Ilincheta de Boschero
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ahmad N Abou TayounPatrick J Dolph
Apr 11, 2012·Biochimica Et Biophysica Acta·Padinjat RaghuNaresh Babu Naidu Mallampati
Feb 9, 2012·Science China. Life Sciences·Yao TianJunhai Han
Jan 11, 2007·Seminars in Cell & Developmental Biology·Padinjat Raghu
Jun 30, 2006·Cell Calcium·Baruch Minke
Apr 14, 2009·Cell Calcium·Padinjat Raghu, Roger C Hardie
Nov 6, 2018·Human Genetics·Pedro GasparAlistair P McGregor
Dec 8, 2007·The Biochemical Journal·Isabel MéridaErnesto Merino
Jun 25, 2019·Frontiers in Cell and Developmental Biology·Rajan ThakurPadinjat Raghu
Sep 16, 2020·Insect Biochemistry and Molecular Biology·Michael Lehmann

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