Dependency and health utilities in stroke: Data to inform cost-effectiveness analyses

European Stroke Journal
Myzoon AliKennedy R Lees

Abstract

Health utilities (HU) assign preference weights to specific health states and are required for cost-effectiveness analyses. Existing HU for stroke inadequately reflect the spectrum of post-stroke disability. Using international stroke trial data, we calculated HU stratified by disability to improve precision in future cost-effectiveness analyses. We used European Quality of Life Score (EQ-5D-3L) data from the Virtual International Stroke Trials Archive (VISTA) to calculate HU, stratified by modified Rankin Scale scores (mRS) at 3 months. We applied published value sets to generate HU, and validated these using ordinary least squares regression, adjusting for age and baseline National Institutes of Health Stroke Scale (NIHSS) scores. We included 3858 patients with acute ischemic stroke in our analysis (mean age: 67.5 ± 12.5, baseline NIHSS: 12 ± 5). We derived HU using value sets from 13 countries and observed significant international variation in HU distributions (Wilcoxon signed-rank test p < 0.0001, compared with UK values). For mRS = 0, mean HU ranged from 0.88 to 0.95; for mRS = 5, mean HU ranged from -0.48 to 0.22. OLS regression generated comparable HU (for mRS = 0, HU ranged from 0.9 to 0.95; for mRS = 5, HU ranged from...Continue Reading

References

Nov 21, 1997·Medical Care·P Dolan
Sep 3, 1999·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·G HawthorneR Osborne
Jan 19, 2000·Medical Decision Making : an International Journal of the Society for Medical Decision Making·S J JansenJ Kievit
Feb 24, 2001·Medical Decision Making : an International Journal of the Society for Medical Decision Making·X BadiaP Kind
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·T O TengsE Luistro
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·P N PostP P Wakker
May 15, 2002·Health Economics·Aki TsuchiyaMakoto Tamura
Dec 18, 2003·Population Health Metrics·Jennifer JelsmaPaul Kind
Aug 8, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Yeon-Kyeng LeeYoung-Tack Kim
Sep 12, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Dominik GolickiJan J V Busschbach
Jun 1, 2005·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·W GreinerJ-M Graf von der Schulenburg
Oct 28, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Oliver Rivero-AriasRamon Luengo-Fernandez
Nov 27, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Helen DakinIan Williamson
Sep 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Rosalie VineyJulie Ratcliffe
Jan 24, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Myzoon AliUNKNOWN VISTA Steering Committees
Nov 28, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David K WhynesUNKNOWN ENOS Investigators
Jan 23, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Louise Longworth, Donna Rowen
Oct 24, 2013·Stroke; a Journal of Cerebral Circulation·Nikola SpriggUNKNOWN Efficacy of Nitric Oxide in Stroke Investigators
Jan 23, 2014·Lancet·Valery L FeiginUNKNOWN Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group
Aug 17, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Gordon G LiuNan Luo

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Citations

Jun 20, 2017·Stroke; a Journal of Cerebral Circulation·Joseph P BroderickJordan Elm
Apr 30, 2020·JAMA Network Open·Alexander D RebchukThalia S Field
Jul 10, 2020·Stroke; a Journal of Cerebral Circulation·Xia WangElse Charlotte Sandset
Sep 14, 2019·Circulation. Cardiovascular Quality and Outcomes·Kristen B SlaughterFarhaan S Vahidy
Feb 13, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Venesha RethnamUNKNOWN AVERT Trial Collaboration Group
Apr 11, 2018·Frontiers in Neurology·Martin Taylor-RowanTerence J Quinn
Mar 10, 2021·European Journal of Preventive Cardiology·Clara MarquinaZanfina Ademi
Mar 27, 2021·Stroke; a Journal of Cerebral Circulation·Mayank GoyalAravind Ganesh
Jun 23, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Clara MarquinaDanny Liew
Jan 18, 2022·PharmacoEconomics·Kaitlyn HastingsZanfina Ademi

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