PMID: 11150699Jan 11, 2001

Dependency of the [18F]fluoromisonidazole uptake on oxygen delivery and tissue oxygenation in the porcine liver

Nuclear Medicine and Biology
Morand PiertR Bares

Abstract

We have previously shown that the accumulation of fluorine-18-labeled fluoromisonidazole ([(18)F]FMISO) is inversely correlated to tissue oxygenation, allowing the quantification of porcine liver tissue hypoxia in vivo. We determined the activity from administered [(18)F]FMISO in relation to the hepatic oxygen availability and the partial pressure of oxygen in tissue (tPO(2)) to define a critical oxygen delivery on a regional basis. [(18)F]FMISO was injected 2 h after onset of regional liver hypoxia due to arterial occlusion of branches of the hepatic artery in 10 domestic pigs. During the experimental procedure the fractional concentration of inspired oxygen (FiO(2)) was set to 0.67 in group A ( N=5) and to 0.21 in group B ( N=5) animals. Immediately before sacrifice, the tPO(2) was determined in normal flow and flow-impaired liver segments. The standardized uptake values (SUV) for [(18)F]FMISO was calculated from 659 single tissue samples obtained 3 h after injection of approximately 10 MBq/kg body weight [(18)F]FMISO and was compared with the regional total hepatic oxygen delivery (DO(2)) calculated from the regional arterial and portal venous flow (based on (141)Ce- and (99m)Tc-microspheres measurements) and the oxygen cont...Continue Reading

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Citations

Nov 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Matthias T WyssSimon M Ametamey
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Michael SørensenSusanne Keiding
Aug 1, 2007·Antioxidants & Redox Signaling·Deepti S VikramPeriannan Kuppusamy
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·D A X SchinaglW J G Oyen
Jan 9, 2009·BMC Health Services Research·Martina WannerAlexander H Schmidt
Sep 3, 2011·Journal of Clinical Bioinformatics·Morihito TakitaMasahiro Kami
Oct 16, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Josef A AlawnehJean-Claude Baron
Feb 5, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Takuya ToyonagaNagara Tamaki
Nov 25, 2005·Chest·Yuh-Chin Tony Huang
Sep 22, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wonsik ChoiSeung Do Ahn
Mar 29, 2008·Stroke; a Journal of Cerebral Circulation·Masashi TakasawaJean-Claude Baron
Mar 12, 2008·Bone Marrow Transplantation·H MuramatsuT Uchiyama
Dec 3, 2005·Pharmazie in unserer Zeit·Hans-Jürgen Machulla

Related Concepts

18F-fluoromisonidazole
Metazoa
Blood Gas Analysis
Electrode
Fluorine Radioisotopes
Hemodynamics
Liver
Latex Spheres
Ro 07-0582
Dioxygen

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