Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig

Prostaglandins
J BonnetP Bessin

Abstract

The Paf-acether (platelet-activating factor) induced bronchospasm (Paf-BCS) was studied in the anesthetized guinea-pig. The SRS antagonist, FPL-55712, as well as inhibitors of both lipoxygenase and cyclooxygenase, phenidone, nordihydroguaiaretic acid (NDGA), and benoxaprofen, caused a dose-related antagonism of Paf-BCS. By contrast, selective inhibitors of cyclooxygenase, indomethacin and aspirin, exerted moderate antagonism at intermediate doses, but had no effect at high doses. Furthermore, diethylmaleate (DEM), which impairs leukotriene synthesis by interfering with glutathione (GSH), suppressed Paf-BCS. Taken together, these results demonstrate that the lipoxygenase pathway plays a major part in the bronchospasmogenic effect of Paf-acether in the guinea-pig.

References

Nov 1, 1979·The Journal of Pharmacy and Pharmacology·J R Walker, W Dawson
Apr 1, 1977·Prostaglandins·S MoncadaP Needleman
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
Apr 1, 1970·Biochemical Pharmacology·E Boyland, L F Chasseaud
Oct 1, 1968·The Biochemical Journal·E Boyland, L F Chasseaud
Mar 7, 1980·European Journal of Pharmacology·F P Nijkamp, A G Ramakers
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C A RouzerZ A Cohn
Dec 1, 1981·The Journal of Clinical Investigation·J M Mencia-HuertaJ Benveniste
Feb 1, 1981·Prostaglandins·A F WeltonB Yaremko
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
Jul 10, 1981·European Journal of Pharmacology·B B VargaftigR C Murphy
Jan 1, 1981·Progress in Lipid Research·B Samuelsson

Citations

Jan 1, 1985·Lung·A B MalikK E Burhop
Jun 22, 1988·European Journal of Pharmacology·J L Wallace, W K MacNaughton
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Aug 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T SakuraiH Nagai
Apr 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S S EdwinM D Mitchell
Jan 1, 1991·Annals of the New York Academy of Sciences·R D Krell, M McCarthy
Oct 1, 1987·The American Review of Respiratory Disease·R R Schellenberg
Apr 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H TsunodaK Katayama
Jan 26, 2007·Pulmonary Pharmacology & Therapeutics·Andrea LessaEduardo Bancalari
Jan 1, 1989·British Journal of Pharmacology·S JancarP Sirois
Jan 1, 1987·British Journal of Pharmacology·M Criscuoli, A Subissi
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adriana R SilvaHugo C Castro-Faria-Neto

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