Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Debanjan ChakrobortySujit Basu

Abstract

It has been recently shown that the catecholamine neurotransmitter dopamine (DA) strongly and selectively inhibits vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-induced angiogenesis. Gastric cancer is highly angiogenic and is dependent on VEGF for its growth and progression. Because substantial amounts of DA present in normal stomach tissues has been implicated in several gastric functions, we therefore investigated the role, if any, of this neurotransmitter in the growth and progression of gastric cancer. Initially, the status of DA and tyrosine hydroxylase, the rate-limiting enzyme required for DA synthesis, were determined in human gastric cancer tissues and in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer tissues of rats. On the basis of our observation of inverse correlation between stomach DA and gastric cancer growth, we determined the effect of pharmacological dose of DA on the angiogenesis and growth of MNNG induced gastric cancer in rats and Hs746T human gastric cancer in nude mice. DA and tyrosine hydroxylase were absent in both human and rat gastric cancer tissues. On the contrary, a low nontoxic pharmacological dose of DA significantly retarded tumor angiogenesis by...Continue Reading

References

May 1, 1997·Journal of Physiology, Paris·B HunyadyE Mezey
Feb 11, 1998·Physiological Reviews·C MissaleM G Caron
Dec 2, 1999·Nature Medicine·N Ferrara, K Alitalo
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L Ma, J L Wallace
Aug 30, 2000·Endocrine·S Basu, P S Dasgupta
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·E Eldrup, E A Richter
Oct 13, 2000·Gastroenterology Clinics of North America·K Kimura
May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y D JungL M Ellis
Oct 3, 2002·Nature Reviews. Cancer·Napoleone Ferrara
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold F Dvorak
May 2, 2003·Cancer Chemotherapy and Pharmacology·Kristan A KeyesBeverly A Teicher

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Citations

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Jan 28, 2009·Endocrine Pathology·María Susana Mallea-GilDamasia Becu-Villalobos
Feb 25, 2006·Nature Reviews. Cancer·Michael H AntoniAnil K Sood
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Debanjan ChakrobortySujit Basu
May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Afsaneh EliassiTaieb Ghasemi
Oct 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pawan K VohraDebabrata Mukhopadhyay
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Myrthala Moreno-SmithAnil K Sood
Mar 15, 2008·The Journal of Clinical Investigation·Debanjan ChakrobortySujit Basu
Jul 30, 2008·Journal of Molecular Signaling·Resham BhattacharyaDebabrata Mukhopadhyay
Dec 15, 2010·Future Oncology·Myrthala Moreno-SmithAnil K Sood
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Gabriel A FramptonSharon Demorrow
May 29, 2010·Journal of Oncology·Jason Tilan, Joanna Kitlinska
Oct 16, 2012·Journal of Cancer Research and Clinical Oncology·Dimitra FlorouAndreas Scorilas
Jan 6, 2015·International Journal of Cancer. Journal International Du Cancer·Chandrani SarkarSujit Basu
Jan 19, 2008·Seminars in Cancer Biology·Premal H Thaker, Anil K Sood
Dec 19, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daniele CampaAage Haugen
Apr 9, 2005·Journal of the American Geriatrics Society·Masanori AsadaHidetada Sasaki
May 13, 2008·International Journal of Cancer. Journal International Du Cancer·Masanori AsadaHiroyuki Arai
Oct 21, 2015·Clinical Hemorheology and Microcirculation·Liangli PanBiao Cheng
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Monique CoufalSharon DeMorrow
Oct 28, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mohammad Esmael AkbariLeili Hosseini
May 28, 2011·Biochimica Et Biophysica Acta·Mario MancinoVanessa Almendro
Mar 4, 2015·Journal of Cell Communication and Signaling·Sushanta K Banerjee
May 20, 2014·Biochimica Et Biophysica Acta·Rajesh N Gacche, Rohan J Meshram
Jun 26, 2012·Brain, Behavior, and Immunity·Guillermo N Armaiz-PenaAnil K Sood
Oct 2, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Marloes A M PetersSjoukje F Oosting
Jun 26, 2007·Developmental Biology·Anita HsounaJanis M O'Donnell
Nov 1, 2016·Journal of Immunology Research·Rodrigo ArreolaLenin Pavón
Feb 6, 2017·International Journal of Cancer. Journal International Du Cancer·Norbert ChauvetNathalie Coutry
Jul 25, 2017·Cancers·Omar ElaskalaniPat Metharom
Aug 2, 2017·International Journal of Molecular Sciences·Xiaoying SunYanna Zhang
Oct 14, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Juan ZouZhongqiu Liu
Mar 5, 2018·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nyanbol KuolKulmira Nurgali
Sep 19, 2019·Oncogene·Shu-Heng JiangZhi-Gang Zhang
Mar 8, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thamara E OsingaIdo P Kema
Apr 26, 2007·The Journal of Clinical Endocrinology and Metabolism·Claudio AlvarezAntonio Pellicer

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