PMID: 15354387Sep 10, 2004Paper

Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates

Journal of Neural Transmission. Supplementum
A HeinzD R Weinberger

Abstract

The radioligand [123I]beta-CIT binds to dopamine transporters in striatum and to serotonin transporters in brainstem. Endogenous dopamine or serotonin may compete with radioligand binding at monoamine transporters. We used alpha-methyl-p-tyrosine (AMPT) to block dopamine production and measured [123I]beta-CIT binding before and after endogenous dopamine was restored by IV administration of the dopamine precursor L-dihydroxyphenylalanine (L-DOPA) in rhesus monkeys. P-chlorophenylalanine (pCPA) was used to inhibit serotonin production, and [123I]beta-CIT binding was assessed before and after IV administration of the serotonin precursor 5-hydroxy-L-tryptophan (L-5-HTP) restored endogenous serotonin. Pretreatment with benserazide blocked peripheral decarboxylization in both paradigms. Serotonin restoration measurably displaced [123I]beta-CIT binding to brainstem serotonin transporters but not to striatal dopamine transporters. Restoration of dopamine apparently did not affect [123I] beta-CIT binding to striatal dopamine transporters. However, dopamine restoration reduced radioligand binding to brainstem serotonin transporters, most likely due to dopamine release from serotonin neurons following L-DOPA administration. The higher str...Continue Reading

Citations

Mar 3, 2006·Journal of Psychopharmacology·Liesbeth RenemanGerard J den Heeten
Feb 3, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Henricus G RuhéAart H Schene
Jul 21, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Pei-Shen HoSan-Yuan Huang
Jun 3, 2011·Nature Reviews. Neuroscience·Adrienne J HeinzAndreas Heinz
May 15, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kelly P CosgroveJulie K Staley

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