Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine

British Journal of Pharmacology
G R Breese, T D Traylor

Abstract

1. After intracisternal administration, 6-hydroxydopamine had a greater effect on brain noradrenaline than on dopamine.2. Administration of two doses of 6-hydroxydopamine increased the depletion of noradrenaline but not of dopamine.3. Small doses of 6-hydroxydopamine decreased the concentration of noradrenaline with little or no effect on dopamine. Tyrosine hydroxylase activity was not reduced with these treatments.4. While pargyline pretreatment offered no advantage in the depletion of brain noradrenaline after 6-hydroxydopamine, depletion of brain dopamine was greatly potentiated by this treatment. The reduction of striatal tyrosine hydroxylase activity observed after 6-hydroxydopamine was also potentiated by pargyline pretreatment.5. The amounts of labelled noradrenaline and dopamine formed from (3)H-tyrosine were greatly reduced by 6-hydroxydopamine treatment. After (3)H-DOPA, formation of noradrenaline was greatly reduced while formation of labelled dopamine was only moderately reduced suggesting that decarboxylation of DOPA can occur in other than catecholamine containing neurones.6. Desmethylimipramine and imipramine inhibited depletion of noradrenaline produced by 6-hydroxydopamine but did not alter depletion of dopamin...Continue Reading

References

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Citations

Aug 1, 1990·Journal of Neuroscience Research·P P Michel, F Hefti
Jul 6, 1978·Psychopharmacology·S M EastgateJ S Werry
Jan 1, 1984·Psychopharmacology·M D Schechter, J T Concannon
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Jan 1, 1989·Journal of Neural Transmission·D L ComminsL S Seiden
Jan 1, 1981·Journal of Neural Transmission·E L SchelkunovM N Ostroumova
Feb 15, 2008·Acta Neuropathologica·Gloria E MeredithMarie-Francoise Chesselet
Jun 11, 1976·Brain Research·W SieghartM Karobath

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