PMID: 7429530Jan 1, 1980Paper

Depletion of C2 and C4 in sera from hamsters bearing herpes simplex type 2-induced tumors

Immunological Communications
E D Márquez

Abstract

Total hemolytic complement activity (CH50) was compared in sera from normal and tumor-bearing hamsters. CH50 ranged from 160-216 in normal animals and from 82 to 152 in tumor-bearing animals. Preliminary screening assays indicated that of 9 complement components assayed, only C2 and C4 showed differences in titer in both normal and tumor-bearer sera. In an expanded study, examination of sera from 12 normal and 14 tumor-bearing hamsters showed that the mean C4 and C2 levels were approximately 88 and 70% below those seen in normal sera, respectively.

References

Jan 1, 1977·International Archives of Allergy and Applied Immunology·F T LewA G Osler
Jan 1, 1978·British Journal of Cancer·C PortaE Clerici
Jan 1, 1976·Annals of the New York Academy of Sciences·K NishiokaK Shimada
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·W P DrakeM R Mardiney
Mar 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·C A DanielsA L Notkins

Related Concepts

Tumor Antigens
Hemolytic Complement
Complement 2
Complement C4, Precursor
Cavia porcellus
Cricetus
Herpes Simplex Infections

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