Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampus.

Molecular and Cellular Neurosciences
Jason P ChanMaribel Rios

Abstract

Granule neurons generated in the adult mammalian hippocampus synaptically integrate to facilitate cognitive function and antidepressant efficacy. Here, we investigated the role of BDNF in facilitating their maturation in vivo. We found that depletion of central BDNF in mice elicited an increase in hippocampal cell proliferation without affecting cell survival or fate specification. However, new mutant neurons failed to fully mature as indicated by their lack of calbindin, reduced dendritic differentiation and an accumulation of calretinin(+) immature neurons in the BDNF mutant dentate gyrus. Furthermore, the facilitating effects of GABA(A) receptor stimulation on neurogenesis were absent in the mutants, suggesting that defects might be due to alterations in GABA signaling. Transcriptional analysis of the mutant hippocampal neurogenic region revealed increases in markers for immature neurons and decreases in neuronal differentiation facilitators. These findings demonstrate that BDNF is required for the terminal differentiation of new neurons in the adult hippocampus.

References

Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G KempermannF H Gage
Oct 10, 1997·Cell and Tissue Research·V RobinsonD G Wilkinson
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Jan 20, 2000·Journal of Neurobiology·S WangJ M Wojtowicz
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J EischE J Nestler
Jun 23, 2000·Biological Psychiatry·T M MadsenA Tingström
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Jun 12, 2001·Current Opinion in Neurobiology·A Patapoutian, L F Reichardt
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·E GouldC G Gross
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Oct 31, 2002·The European Journal of Neuroscience·Jennifer R ChaoEric J Nestler
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarina B ElmariahRita J Balice-Gordon
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lisa M MonteggiaEric J Nestler
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Sep 25, 2004·Journal of Cellular Physiology·Radka StoyanovaAlfonso Bellacosa
Oct 21, 2004·Nature Neuroscience·A Denise R GarciaMichael V Sofroniew
Nov 13, 2004·The EMBO Journal·Si Tuen Lee-HoeflichLiliana Attisano
Nov 24, 2004·The International Journal of Developmental Biology·Susana Cohen-Cory, Barbara Lom
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikko SairanenEero Castrén
May 21, 2005·Mechanisms of Development·Allan M GoldsteinDrucilla J Roberts
May 25, 2005·Molecular and Cellular Neurosciences·Li-Ping WangHelmut Kettenmann
Jul 22, 2005·Journal of Neurophysiology·Linda Overstreet WadicheGary L Westbrook

❮ Previous
Next ❯

Citations

Jul 22, 2009·Experimental Brain Research·Michael J ColditzElizabeth J Coulson
Nov 17, 2010·Molecular Psychiatry·B LuscherN Sahir
Jan 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin G BathIpe Ninan
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Katsunori KobayashiHidenori Suzuki
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Heiko WurdakPeter G Schultz
Dec 23, 2009·Molecular Neurodegeneration·Se Hoon ChoiSangram S Sisodia
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emily G WaterhouseBaoji Xu
Feb 24, 2016·Frontiers in Neuroscience·Marçal Vilar, Helena Mira
Feb 3, 2016·Frontiers in Neuroscience·María Llorens-MartínJesús Ávila
Jan 19, 2010·Current Opinion in Neurobiology·Guangnan Li, Samuel J Pleasure
Jul 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Evelin L SchaefferAlvaro G Mendes-Neto
Sep 2, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Piyush ChaturbedyMuthusamy Eswaramoorthy
May 20, 2011·Developmental Neurobiology·Caghan KizilMichael Brand
Jan 20, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Danielle E HarlowLinda A Barlow
Apr 18, 2012·The European Journal of Neuroscience·Clarissa SchitineJoão O Malva
Feb 22, 2012·Journal of Cellular and Molecular Medicine·Isabelle LoubinouxAurel Popa-Wagner
Mar 15, 2011·The European Journal of Neuroscience·Katharina MerzD Chichung Lie
Jul 5, 2011·The European Journal of Neuroscience·Venceslas DuveauJean-Marc Fritschy
Apr 11, 2012·Developmental Neurobiology·Matteo Bergami, Benedikt Berninger
Jul 30, 2015·Neurochemistry International·X Du, R A Hill
Dec 25, 2012·Experimental Neurology·Huan LiuKathleen M Guthrie
Apr 17, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Luciana PietraneraAlejandro F De Nicola
Apr 14, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sajjad RezaeiEhsan Kazemnejad Leili
Mar 26, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K E BoschenA Y Klintsova
Nov 30, 2010·Neurobiology of Learning and Memory·Zhiwei XuChenggang Zhang
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Alejandro Amador-ArjonaAlexey V Terskikh
Jul 15, 2009·Journal of Hepatology·Iddo MagenElliot M Berry
Jan 8, 2015·Frontiers in Cellular Neuroscience·Francesca CalabreseRaffaella Molteni
Apr 2, 2014·Frontiers in Synaptic Neuroscience·Yves KellnerMartin Korte
Aug 16, 2016·Journal of Molecular Neuroscience : MN·X Du, R A Hill
Sep 14, 2016·Journal of Chemical Neuroanatomy·Jariya Umka WelbatPeter Wigmore
Oct 27, 2016·Journal of Neuroscience Research·Aggeliki GiannakopoulouNikolaos Grigoriadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Fate Specification

Cell fate specification is determined by complex signal transduction pathways including Notch and the Sonic hedgehog signaling pathway. Here is the latest research on regulation of cell fate determination.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis