Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output

Brain Research
L DazziG Biggio

Abstract

In freely moving rats finasteride markedly reduced the cortical content of allopregnanolone. This treatment significantly prolonged the increase in the extracellular concentration of dopamine in the prefrontal cortex induced by foot shock. Moreover, finasteride enhanced both maximal increase of dopamine and its duration elicited by a single injection of the anxiogenic drug FG 7142. These results suggest that endogenous allopregnanolone may modulate the excitatory response of cortical dopaminergic neurons to stressful and anxiogenic stimuli.

References

May 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H PurdyS M Paul
Sep 1, 1995·Trends in Pharmacological Sciences·J J LambertJ A Peters
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·V UzunovaA Guidotti
Jan 6, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S V Argyropoulos, D J Nutt

❮ Previous
Next ❯

Citations

Jan 20, 2007·Cellular and Molecular Neurobiology·Erin M MacKenzieGlen B I Baker
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Patrizia PorcuAlessandra Concas
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·M Molina-HernándezM Teresa Jaramillo
May 30, 2002·Brain Research. Brain Research Protocols·Giuseppe TrapaniGiovanni Biggio
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco BortolatoGian L Gessa
Jul 24, 2010·Canadian Journal of Physiology and Pharmacology·Hacène FrihAbdel Majid Bairi
Oct 13, 2009·Hormones and Behavior·Marilyn E Carroll, Justin J Anker
Dec 14, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernándezM Teresa Jaramillo
Sep 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anjana Bali, Amteshwar Singh Jaggi
Jul 6, 2016·Frontiers in Cellular Neuroscience·Valeria LallaiLaura Dazzi
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Alicia A Walf
Nov 26, 2014·Alcoholism, Clinical and Experimental Research·Anushree N KarkhanisSara R Jones
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rajesh R UgaleChandrabhan T Chopde
Dec 21, 2018·Climacteric : the Journal of the International Menopause Society·A GianniniT Simoncini
Jul 15, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura DazziGiovanni Biggio
Jun 8, 2018·Frontiers in Public Health·Juan Pablo Del RíoPilar Vigil
May 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shiyi ChenYiping Ye
Jul 1, 2021·Journal of Neuroendocrinology·Silvia DiviccaroRoberto Cosimo Melcangi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.