Depletion of cutaneous nerves and neuropeptides in diabetes mellitus: an immunocytochemical study.

Diabetologia
D M LevyJ M Polak

Abstract

Immunocytochemistry for the general neuronal marker protein gene product 9.5 and four neuropeptides (calcitonin gene-related peptide, substance P, vasoactive intestinal polypeptide and neuropeptide Y) was performed on 20 skin biopsy specimens from 19 diabetic patients, age range 20-75 years, 17 Type 2 (non-insulin-dependent) and 3 Type 1 (insulin-dependent). Fifteen specimens were from the lower limb, 3 from the upper limb and 2 from the abdominal wall. Seven subjects had lower limb neurophysiological tests. All but one specimen showed reduced protein gene product 9.5 and neuropeptide immunoreactivity. Reduced protein gene product 9.5 and neuropeptide immunoreactivity was found in specimens taken from the abdominal wall and hand as well as those from the leg, and also in specimens from patients undergoing amputation for peripheral vascular disease. In general, the greater the number of abnormal neurophysiological tests, the greater the extent of neuronal abnormalities. Three patients with normal tests had abnormalities of dermal innervation. While these changes are also found in other axonal neuropathies, in the absence of other causes of peripheral nerve disease and of macrovascular disease, immunocytochemistry of skin biopsie...Continue Reading

References

Sep 1, 1975·Brain : a Journal of Neurology·F BehseG G Knappeis
Mar 1, 1986·Electroencephalography and Clinical Neurophysiology·R R AbrahamV Wynn
Sep 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·J JakobsenH Braendgaard
Apr 1, 1987·British Medical Bulletin·J C Foreman
Dec 1, 1987·British Journal of Pharmacology·R W FullerP J Barnes
Oct 25, 1986·British Medical Journal·P G NewrickJ D Ward
Jan 1, 1987·Diabetes Care·B R Zimmerman
Jan 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·N Parkhouse, P M Le Quesne
Jan 1, 1983·Clinical and Experimental Dermatology·S R Bloom, J M Polak
Jul 1, 1984·Harefuah·I Steiner, Z Argov
Nov 14, 1983·Brain Research·R J ThompsonJ Rode
Mar 1, 1984·Diabetes·P C Johnson, S C Doll
May 1, 1984·Annals of Neurology·W R KennedyF C Goetz
Jul 1, 1984·The American Journal of Medicine·G K MorleyJ E Morley
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Jul 1, 1981·Journal of the Neurological Sciences·J Fagius, L K Wahren

❮ Previous
Next ❯

Citations

Sep 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·H LindL Edvinsson
Jun 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·T J BergR R Abraham
Apr 13, 1991·Lancet
Mar 1, 1992·Journal of the Autonomic Nervous System·D AnderssonL Edvinsson
Apr 20, 2004·Regulatory Peptides·Tashfeen AhmadAndris Kreicbergs
Feb 19, 1997·European Journal of Pharmacology·M UchiyamaN Toda
Jan 6, 2000·Journal of the Neurological Sciences·A HiraiR Kikkawa
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Jan 14, 2009·Expert Reviews in Molecular Medicine·Leena PradhanAristidis Veves
May 31, 2001·Clinical and Experimental Pharmacology & Physiology·R LuY J Li
Jul 27, 2001·Diabetes Technology & Therapeutics·M PolydefkisJ C McArthur
Jul 27, 2001·Diabetes Technology & Therapeutics·A I VinikK B Stansberry
May 7, 2004·Brain : a Journal of Neurology·Chia-Tung ShunSung-Tsang Hsieh
Sep 24, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bruna R SouzaAndréa M A Costa
Jun 1, 1993·The British Journal of Dermatology·D J Eedy
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·D M LevyD A Rowley
Jan 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·P C Johnson, J L Beggs
Mar 6, 2003·Experimental Neurology·Julie A ChristiansonDouglas E Wright
Sep 13, 2005·Current Opinion in Neurology·Kelli A Sullivan, Eva L Feldman
Feb 16, 2016·European Journal of Pharmacology·Rabya SarafRobina Matyal
Apr 7, 2009·European Journal of Pharmacology·Bruna Romana-SouzaAndréa Monte-Alto-Costa
Dec 18, 2002·The Journal of Investigative Dermatology·MarcosA AntezanaJohnE Olerud
Sep 4, 2009·The Journal of Investigative Dermatology·Bérengère FromyJean Louis Saumet
Apr 4, 2008·Acta histochemica·Kristina K BeiswengerAndrew P Mizisin
Jun 22, 2007·Lancet Neurology·Claudia Sommer, Giuseppe Lauria
Oct 12, 2007·Experimental Neurology·Andrea M VincentEva L Feldman
Aug 15, 2009·Diabetes/metabolism Research and Reviews·Clare Y L Chao, Gladys L Y Cheing
Jun 9, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·R Blakytny, E Jude
Jul 22, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jeffrey R ScottNicole S Gibran
Jan 16, 2007·Muscle & Nerve·T UmapathiYiong Huak Chan
Jul 22, 2008·Histopathology·G LauriaG Devigili

❮ Previous
Next ❯

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