Depletion of dietary sulphamonomethoxine and sulphadimethoxine from various tissues of laying hens

British Poultry Science
N FurusawaH Ohori

Abstract

Sulphamonomethoxine (SMM) or sulphadimethoxine (SDM) was fed to laying hens at 400 mg/kg diet for 5 successive days. After withdrawal of the drugs, contents (mg/kg) of SMM and SDM in the blood, kidney, liver, ovary, muscle and adipose tissue were determined by HPLC. 2. The disappearance of dietary SMM and SDM from the tissues of laying hens was rapid and, except for the liver, was very similar in all tissues. 3. A common biological half-life (t1/2) of SMM in the above 6 tissues was estimated to be 5.2 h. The t1/2 of SDM in the liver was 6.9 h, significantly longer than that of 4.4 h in the other 5 tissues. The values were much shorter than 51/2 (reported elsewhere) for other drugs. 4. Comparing the data found in this study with those obtained from previous papers, the depletion velocities of SMM and SDM from the hen's body were much faster than those from albumen in egg. The reason for this is probably related to the longer time period over which albumen formation occurs.

References

Feb 1, 1978·Zentralblatt für Veterinärmedizin. Reihe A·M AtefS M Sokkar
May 1, 1977·Poultry Science·H OikawaK Katagiri
Sep 1, 1990·British Poultry Science·B Roudaut, J P Moretain
Aug 19, 1971·Biochimica Et Biophysica Acta·C I Osuoji

Citations

Sep 16, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A OzakiH Yamaguchi
Jul 3, 1998·British Poultry Science·N FurusawaH Yamaguchi
Apr 19, 2002·Food Additives and Contaminants·B Roudaut, M Garnier
Aug 28, 1998·Zentralblatt für Veterinärmedizin. Reihe A·N Furusawa
Feb 24, 2015·Food Chemistry·Nina BilandžićŽeljko Cvetnić
Aug 5, 2018·Journal of Veterinary Pharmacology and Therapeutics·Trishna PatelLisa A Tell

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