PMID: 25762631Mar 13, 2015Paper

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

Oncotarget
Bertal H AktasJose A Halperin

Abstract

Most sporadic breast and ovarian cancers express low levels of the breast cancer susceptibility gene, BRCA1. The BRCA1 gene produces two transcripts, mRNAa and mRNAb. mRNAb, present in breast cancer but not in normal mammary epithelial cells, contains three upstream open reading frames (uORFs) in its 5'UTR and is translationally repressed. Comparable tandem uORFs are characteristically seen in mRNAs whose translational efficiency paradoxically increases when the overall translation rate is decreased due to phosphorylation of eukaryotic translation initiation factor 2 α (eIF2α). Here we show fish oil derived eicosopanthenoic acid (EPA) that induces eIF2α phosphorylation translationally up-regulates the expression of BRCA1 in human breast cancer cells. We demonstrate further that a diet rich in EPA strongly induces expression of BRCA1 in human breast cancer xenografts.

References

Aug 27, 1990·Biochimica Et Biophysica Acta·P F Miller, A G Hinnebusch
Apr 25, 1986·Cell·P P Mueller, A G Hinnebusch
Oct 7, 1994·Science·P A FutrealY Miki
Dec 1, 1995·Human Molecular Genetics·C F XuE Solomon
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerJ M Lehmann
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·H AktasJ A Halperin
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·J TaylorS Ali
Feb 24, 2000·Gynecologic Oncology·W ZhengM C Pike
Apr 6, 2000·Journal of the National Cancer Institute·M EstellerJ G Herman
Nov 28, 2000·The Journal of Biological Chemistry·S DasU Maitra
Mar 6, 2002·The Journal of Biological Chemistry·Krzysztof Sobczak, Wlodzimierz J Krzyzosiak
Apr 17, 2002·Japanese Journal of Clinical Oncology·Kazuaki MiyamotoToshikazu Ushijima
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Piri L WelcshMary-Claire King
May 20, 2003·The Journal of Pathology·H LambieI O Ellis
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Meena Jhanwar-Uniyal
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Krishna M Vattem, Ronald C Wek
Aug 31, 2004·The Journal of Nutrition·Huseyin Aktas, Jose A Halperin
Mar 24, 2005·Journal of Cellular and Molecular Medicine·R G Dumitrescu, I Cotarla
Jan 26, 2006·JAMA : the Journal of the American Medical Association·Catherine H MacLeanSally C Morton
Oct 3, 2006·Journal of Molecular Biology·Vladimir GelevGerhard Wagner
Jan 5, 2007·The Journal of Biological Chemistry·Madhusudan DeyThomas E Dever
May 28, 2011·International Journal of Cancer. Journal International Du Cancer·Holger HeynCarmela Beger
Jul 19, 2011·Nature Chemical Biology·Ting ChenBertal H Aktas
Dec 14, 2011·Bioorganic & Medicinal Chemistry Letters·Séverine DenoyelleMichael Chorev
Jun 21, 2013·Chembiochem : a European Journal of Chemical Biology·Huijun BaiBertal H Aktas
Jul 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie RenMinjie Wei
Oct 5, 2013·Oncotarget·Bertal H AktasJose A Halperin
Oct 31, 2013·Journal of the National Cancer Institute·Chaoyang SunGang Chen
Jan 30, 2014·PloS One·Elisabetta CrippaMarco Alessandro Pierotti
Mar 22, 2014·Molecular Biology of the Cell·Thomas D BairdRonald C Wek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

Nature
M A BrownR McFarlane
Hereditary Cancer in Clinical Practice
Bohdan Górski, Jan Lubinski
Genes, Chromosomes & Cancer
Richard A DiCioccioM Steven Piver
British Journal of Cancer
I G CampbellD M Eccles
© 2021 Meta ULC. All rights reserved