Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation

Pain
Wahida RahmanAnthony H Dickenson

Abstract

There is compelling evidence for a strong facilitatory drive modulating spinal nociceptive transmission. This is in part via serotonergic pathways and originates from the rostroventral medulla. We previously demonstrated that neuropathic pain is associated with an enhanced descending facilitatory drive onto the mechanical evoked responses of dorsal horn neurones, mediated by 5-HT acting at spinal 5-HT3 receptors. Furthermore, depletion of spinal 5-HT has been shown to reduce the at-level mechanical allodynia that follows spinal cord injury. To further clarify the role and direction of effect of endogenous 5-HT, we investigated the effects of depleting spinal 5-HT, via intrathecal injection of 5,7di-hydroxytryptamine (5,7DHT), on pain behaviours after spinal nerve ligation (SNL). Depletion of spinal 5-HT in normal animals leads to reductions in mechanical and thermal evoked responses of deep dorsal horn neurones implying that spinal 5-HT has a predominant facilitatory function. After nerve injury, the frequency of paw withdrawals to low intensity mechanical and cooling stimulation of the ipsilateral hindpaw in the SNL-5,7DHT group was significantly attenuated when compared with the SNL-saline group from day seven post-nerve inju...Continue Reading

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Citations

Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kirsty BannisterAnthony H Dickenson
Apr 20, 2010·Journal of Neuroinflammation·Lawrence Leung, Catherine M Cahill
May 12, 2012·Anesthesia and Analgesia·Masafumi KimuraShigeru Saito
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mai Lan LeongMartin Wessendorf
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming GuFeng Wei
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng WeiWei Guo
Nov 24, 2011·Pain Research and Treatment·Lucie A Low, Petra Schweinhardt
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Feb 29, 2016·Pharmacological Reports : PR·Claudia Cervantes-DuránVinicio Granados-Soto
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Nov 22, 2013·Pain Practice : the Official Journal of World Institute of Pain·Mikwang KwonLevent Alev
Jul 15, 2015·Brain Research·Sabino Hazael Avila-RojasVinicio Granados-Soto
Jan 27, 2015·Drug Development Research·Jorge B Pineda-FariasVinicio Granados-Soto
Feb 1, 2012·Pharmacology, Biochemistry, and Behavior·Mariana Bravo-HernándezVinicio Granados-Soto
Jun 23, 2011·Pharmacology, Biochemistry, and Behavior·Evelyn Amaya-CastellanosVinicio Granados-Soto

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