Depletion of Omega-3 Fatty Acids in RBCs and Changes of Inflammation Markers in Patients With Morbid Obesity Undergoing Gastric Bypass.

The Journal of Nutrition
Tahar HajriHans Schmidt

Abstract

Bariatric surgery is considered the most effective treatment for severe obesity. Despite this wide success, bariatric surgery is associated with increased risks of nutritional deficiencies. To examine whether Roux-en-Y-gastric bypass (RYGB) alters essential fatty acid (FA) status and inflammation markers. Subjects with obesity (n = 28; BMI > 40 kg/m2; mean age 48 years) were studied before and 1 year after RYGB. We collected blood samples before and 12 months after RYGB, and analyzed FA in RBCs and peripheral blood mononuclear cells (PBMC), and measured inflammation parameters in plasma. The proportion of total n-3 FAs was the primary outcome, while parameters related to other FAs and inflammation factors were the secondary parameters. In addition, PBMCs from 15 of the participants were cultured alone or with 100 and 200 μM DHA, and the production of IL-6, IL-1β, PGE2, and prostaglandin F2-alpha (PGF2α) was assayed after endotoxin (LPS) stimulation. RYGB induced a significant reduction of BMI (-30%) and improvement of insulin resistance (-49%). While the proportion of arachidonic acid was 15% higher after RYGB, the proportions of total and individual n-3 FAs were 50%-75% lower (P < 0.01). Consequently, the RBC omega-3 index and...Continue Reading

References

Jul 13, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C HoldstockF A Karlsson
May 16, 2008·Journal of Lipid Research·M Rabie Al-TurkmaniMichael Laposata
Jun 11, 2008·The American Journal of Clinical Nutrition·William S Harris
Oct 28, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Philip C Calder
Dec 5, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Timothy D MickleboroughMartin R Lindley
Feb 27, 2009·The Journal of Nutrition·William S HarrisJay Whelan
May 21, 2009·The British Journal of Nutrition·Michelle MicallefManohar Garg
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·A ViardotK Samaras
Nov 11, 2010·American Journal of Physiology. Endocrinology and Metabolism·Tahar HajriNaji N Abumrad
Mar 4, 2011·The American Journal of Clinical Nutrition·Tanya L BlasbalgRobert R Rawlings
Apr 12, 2012·Diabetes/metabolism Research and Reviews·A ViardotK Samaras
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Paul C Norris, Edward A Dennis
Jul 7, 2012·Journal of Lipid Research·Shurong HuangDaniel H Hwang
Mar 22, 2013·Obesity Surgery·Kimberly A GudzuneJeanne M Clark
Nov 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Julie LasselinLucile Capuron
Nov 21, 2013·Journal of the American Heart Association·Michael R FlockPenny M Kris-Etherton
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Meriem AbdennourKarine Clement
Mar 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Estelle F DevêvreChristine Poitou
Sep 1, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A S KellyT H Inge
Jan 4, 2017·The Journal of Clinical Investigation·Alan R Saltiel, Jerrold M Olefsky
Jun 14, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jayshil J PatelRobert G Martindale
Jul 29, 2017·Clinical and Translational Medicine·Rafael ZárateCovadonga Rodríguez
Sep 14, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I P FischerS Ussar
Nov 2, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Hernandez-CarreteroO Osborn
Mar 31, 2018·Nutrients·Marcelo Macedo Rogero, Philip C Calder
Jul 14, 2018·Diabetes/metabolism Research and Reviews·Nadeeja N WijayatungaNaima Moustaid-Moussa
Aug 2, 2018·Journal of Leukocyte Biology·Lynn M FrydrychMatthew J Delano
Aug 15, 2018·Obesity Surgery·Pirjo KäkeläJussi Pihlajamäki
Oct 13, 2018·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Hans J SchmidtDouglas R Ewing

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