Depletion of resting zone chondrocytes during growth plate senescence

The Journal of Endocrinology
Lenneke SchrierJ Baron

Abstract

With age, the growth plate undergoes senescent changes that cause linear bone growth to slow and finally cease. Based on previous indirect evidence, we hypothesized that this senescent decline occurs because growth plate stem-like cells, located in the resting zone, have a finite proliferative capacity that is gradually depleted. Consistent with this hypothesis, we found that the proliferation rate in rabbit resting zone chondrocytes (assessed by continuous 5-bromo-2'-deoxy-uridine labeling) decreases with age, as does the number of resting zone chondrocytes per area of growth plate. Glucocorticoid excess slows growth plate senescence. To explain this effect, we hypothesized that glucocorticoid inhibits resting zone chondrocyte proliferation, thus conserving their proliferative capacity. Consistent with this hypothesis, we found that dexamethasone treatment decreased the proliferation rate of rabbit resting zone chondrocytes and slowed the numerical depletion of these cells. Estrogen is known to accelerate growth plate senescence. However, we found that estradiol cypionate treatment slowed resting zone chondrocyte proliferation. Our findings support the hypotheses that growth plate senescence is caused by qualitative and quanti...Continue Reading

Citations

Nov 11, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anenisia C AndradeOla Nilsson
Nov 2, 2007·Leukemia·F ZamanL Sävendahl
Dec 13, 2012·Journal of Pediatric Orthopedics·Tiffiny A Butler, Vanessa R Yingling
Dec 12, 2012·Journal of Animal Science and Biotechnology·Logan B SmithAnita M Oberbauer
Mar 29, 2011·Endocrine Reviews·Julian C Lui, Jeffrey Baron
Jan 17, 2015·Nutrients·Galia Gat-Yablonski, Moshe Phillip
Aug 21, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Andreas TagarielloAndreas Winterpacht
Apr 22, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chanika PhornphutkulQian Chen
Jul 25, 2007·Clinical Endocrinology·R J PerryS F Ahmed
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yosuke KamiyaSunil Wadhwa
Oct 2, 2014·Journal of Anatomy·Ayman A Al Dayeh, Susan W Herring
Jan 10, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Sun Haeng LeeGyu Tae Chang
Apr 5, 2018·The Journal of Endocrinology·Majdi MasarwiGalia Gat-Yablonski
Jan 3, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yu UsamiMotomi Enomoto-Iwamoto
Oct 21, 2015·Endocrine Reviews·Alberto Roselló-Díez, Alexandra L Joyner
Jan 31, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Campbell Rolian
Feb 5, 2016·Physiological Reviews·Kerstin HartmannJan P Tuckermann
May 22, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Maria A SerratDonna King
May 22, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Brett J Kagan, Alberto Rosello-Diez
Jun 24, 2017·Orthodontics & Craniofacial Research·J L RobinsonS Wadhwa
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Hélène DavidDominique Simon
May 18, 2020·Current Osteoporosis Reports·Holly L Racine, Maria A Serrat
Oct 27, 2015·Biology Open·Kyriel M PineaultDeneen M Wellik

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