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Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis

PloS One

Sep 8, 2012

Paul T ArsenovicTim A Bloss

Abstract

The nascent polypeptide-associated complex (NAC) is a highly conserved heterodimer important for metazoan development, but its molecular function is not well understood. Recent evidence suggests the NAC is a component of the cytosolic chaperone network that interacts with ribosomal comp...read more

Mentioned in this Paper

Calcinus elegans
Embryo
Cyartonema elegans
Establishment and Maintenance of Localization
Hspa5 protein, mouse
Coleonyx elegans
Response to Heat
Heat shock proteins
Biochemical Pathway
Biological Adaptation to Stress
Paper Details
References
  • References48
  • Citations13
  • References48
  • Citations13
12

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Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis

PloS One

Sep 8, 2012

Paul T ArsenovicTim A Bloss

PMID: 22957041

DOI: 10.1371/journal.pone.0044038

Abstract

The nascent polypeptide-associated complex (NAC) is a highly conserved heterodimer important for metazoan development, but its molecular function is not well understood. Recent evidence suggests the NAC is a component of the cytosolic chaperone network that interacts with ribosomal comp...read more

Mentioned in this Paper

Calcinus elegans
Embryo
Cyartonema elegans
Establishment and Maintenance of Localization
Hspa5 protein, mouse
Coleonyx elegans
Response to Heat
Heat shock proteins
Biochemical Pathway
Biological Adaptation to Stress

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ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

Related Papers

The EMBO Journal

The nascent polypeptide-associated complex is a key regulator of proteostasis

The EMBO JournalApril 23, 2013
Janine Kirstein-MilesRichard I Morimoto
Paper Details
References
  • References48
  • Citations13
  • References48
  • Citations13
12
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