Depletion of the lncRNA RP11-567G11.1 inhibits pancreatic cancer progression

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ranglang HuangJing Chou

Abstract

Pancreatic cancer is one of the most lethal malignancies, as demonstrated by its 5-year survival rate of less than 10%. The poor response of pancreatic cancer to conventional therapeutics, especially against cancer stem cells (CSCs), is the primary obstacle to improving patient survival. Emerging evidence indicates that the long non-coding RNA (lncRNA) RP11-567G11.1 is up-regulated in pancreatic cancer tissues and that its expression is associated with poor prognosis. This study aimed to elucidate the mechanism by which RP11-567G11.1 influences survival in pancreatic cancer. We evaluated the expression of RP11-567G11.1 in pancreatic cancer tissues via in situ hybridization. We also constructed RP11-567G11.1 knockdown cell models and used CCK8 and flow cytometry to detect the function of this lncRNA. Western blotting and qPCR were used to detect the expression levels of factors related to RP11-567G11.1. The results illustrated that RP11-567G11.1 was significantly up-regulated in poorly differentiated pancreatic cancer tissues as compared to its expression in non-tumor tissues. Additionally, depletion of RP11-567G11.1 in pancreatic cancer cells inhibited proliferation and cell cycle progression, induced apoptosis, suppressed the ...Continue Reading

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Citations

Sep 15, 2020·Cancer Biomarkers : Section a of Disease Markers·Tao JiXiaoming Zhang
Mar 21, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
Apr 4, 2021·Cancers·Leila JahangiriSuzanne D Turner
May 27, 2021·Transcription·K T Ramya DeviSanjana Prakash Hemdev
Jul 3, 2021·International Journal of Molecular Sciences·Jorge Melendez-Zajgla, Vilma Maldonado

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