PMID: 9174977Apr 1, 1997Paper

Depletion of tumor necrosis factor-alpha in mice by Nyctanthes arbor-tristis

Journal of Ethnopharmacology
B N Paul, A K Saxena

Abstract

The effect of the water soluble fraction of the ethanol extract of Nyctanthes arbor-tristis (NAT) on tumor necrosis factor-alpha (TNF-alpha) level in plasma of arthritic and soluble protein A (SpA)-treated Balb/c mice has been studied. Oral administration of this fraction in arthritic mice showed a consistent depletion of TNF-alpha from the host plasma. A similar depletion of TNF-alpha in the plasma of SpA-treated mice has been observed. The extract also reduces plasma interferon-gamma level but the plasma IgM and IgG levels are not affected. The implications of these observations are discussed in the light of management of TNF-alpha in clinical disorders.

References

Feb 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P BellucoR M Gaion
Jul 1, 1992·International Journal of Immunopharmacology·B N PaulP K Ray
Jul 1, 1991·Journal of Natural Products·J S TandonP Y Guru
Mar 1, 1988·The Journal of Infectious Diseases·K J TraceyA Cerami
Jan 1, 1987·Ciba Foundation Symposium
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·A Cerami, B Beutler
Mar 1, 1987·Journal of Ethnopharmacology·R S SaxenaD N Prasad
Mar 1, 1994·Journal of Ethnopharmacology·A PuriJ S Tandon
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·B B NEWBOULD

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Citations

Apr 9, 2008·Journal of Clinical Biochemistry and Nutrition·Brijesh RathoreSiddharth Kumar Das
Feb 5, 2013·Journal of Ethnopharmacology·Jyoti Agrawal, Anirban Pal
Dec 5, 2016·Journal of Ayurveda and Integrative Medicine·Chhaya S GodseAshok D B Vaidya

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