Deployment of convalescent plasma for the prevention and treatment of COVID-19.

The Journal of Clinical Investigation
Evan M BlochAaron Ar Tobian


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. Immune (i.e., "convalescent") plasma refers to plasma that is collected from individuals following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy for conferring immediate immunity to susceptible individuals. There are numerous examples in which convalescent plasma has been used successfully as postexposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East respiratory syndrome [MERS]). Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads, and improved survival. Globally, blood centers have robust infrastructure for undertaking collections and constructing inventories of convalescent plasma to meet the growing demand. Nonetheless, t...Continue Reading


Jul 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, M D Scharff
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·A Casadevall, M D Scharff
Sep 4, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lingkui Kong
Sep 12, 2003·Trends in Immunology·Arturo Casadevall, Liise-anne Pirofski
Sep 17, 2004·Nature Reviews. Microbiology·Arturo CasadevallLiise-anne Pirofski
Dec 24, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ChengG Cheng
Aug 27, 2005·Journal of Medical Virology·Jian-San ZhangWei-Dong Yin
Sep 27, 2005·The Journal of Antimicrobial Chemotherapy·Kuo-Ming YehFeng-Yee Chang
Aug 31, 2006·Annals of Internal Medicine·Thomas C LukeStephen L Hoffman
Oct 5, 2007·The New England Journal of Medicine·Boping ZhouYi Guan
Feb 20, 2009·Anesthesia and Analgesia·Jeanne E Hendrickson, Christopher D Hillyer
Jan 21, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ivan Fn HungKwok-Yung Yuen
Apr 23, 2013·Cell Host & Microbe·Siu-Kei ChowArturo Casadevall
Aug 18, 2016·Emerging Infectious Diseases·Yaseen M ArabiMashail Alahmadi
Nov 4, 2017·Science·Leah C KatzelnickEva Harris
Feb 28, 2019·Blood·Michael P BuschSteven Kleinman
Apr 11, 2019·Frontiers in Immunology·Elisabeth A van ErpPuck B van Kasteren
Dec 13, 2019·Journal of Virology·Yushun WanFang Li
Feb 25, 2020·Microbes and Infection·Jason A Tetro
Mar 3, 2020·Lancet·Yang LiuAdam J Kucharski
Mar 3, 2020·The Lancet Infectious Diseases·Long ChenYuan Shi
Mar 7, 2020·MMWR. Morbidity and Mortality Weekly Report·Rachel M BurkeMelissa A Rolfes
Mar 14, 2020·The Journal of Clinical Investigation·Arturo Casadevall, Liise-Anne Pirofski
Mar 15, 2020·The Lancet Infectious Diseases·Adam J KucharskiUNKNOWN Centre for Mathematical Modelling of Infectious Diseases COVID-19 working group
Mar 18, 2020·Pediatrics·Yuanyuan DongShilu Tong
Mar 19, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Kenji MizumotoGerardo Chowell
Mar 28, 2020·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN CDC COVID-19 Response Team
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Fatima AmanatFlorian Krammer
Mar 23, 2020·MedRxiv : the Preprint Server for Health Sciences·K. DuanX. Yang

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Sep 29, 2020·Scientific Reports·Cong-Ying SongYuan-Qiang Lu
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