PMID: 9550295Apr 29, 1998Paper

Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon

Naunyn-Schmiedeberg's Archives of Pharmacology
A LippiC A Maggi

Abstract

The aim of this study was to assess at which extent an even co-release of the tachykinins, substance P (SP) and neurokinin A (NKA), occurs from enteric neurons/nerves of the guinea-pig proximal colon during graded depolarization. In this preparation, a sharply diverging NK1/NK2 receptor pattern of tachykininergic co-transmission has been observed in physiological studies. The experiments were performed in capsaicin-pretreated (10 microM for 15 min) mucosa-free smooth muscle of guinea-pig proximal colon, to exclude the mucosa and the peripheral endings of primary afferent nerves as possible sources of released tachykinins. The content of extractable tachykinins was measured as SP- and NKA-like immunoreactivities (-LI) by radioimmunoassay. Chromatographic characterization of aqueous acetic acid extracts showed one peak of SP-LI corresponding to authentic SP, whereas there were multiple peaks of NKA-LI, the major one co-eluting with authentic NKA. An increased outflow of both SP- and NKA-LI was evenly produced in a concentration-dependent manner when the preparations were superfused with a high potassium (K) medium in which NaCl had been replaced with equimolar amounts (20-100 mM) of KCl. The high K-evoked release of SP- and NKA-L...Continue Reading

Citations

Jun 28, 2000·Journal of the Autonomic Nervous System·J B Furness
Dec 17, 2002·Current Opinion in Pharmacology·John B Furness, Gareth J Sanger
Feb 24, 2001·Mediators of Inflammation·C VieiraS Manzini
Dec 9, 2010·The Journal of Veterinary Medical Science·Hayato MatsuyamaTadashi Takewaki
Jul 19, 2014·European Journal of Pharmacology·Shu-ichi KojimaNaohiko Anzai
Aug 18, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Viktoria DénesRobert Gábriel
Apr 18, 2006·Autonomic Neuroscience : Basic & Clinical·Alessandro LecciCarlo Alberto Maggi
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M ToulouseL Buéno
Mar 21, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F De PontiG M Frigo
Feb 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiaochun BianJames J Galligan
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L OnoriM Tonini
Sep 3, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eileen Rodriguez-TapiaJames J Galligan
Dec 23, 2016·Experimental Physiology·Eileen S Rodriguez-TapiaJames J Galligan

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