PMID: 9159628May 1, 1997Paper

Depolarizing cardiac arrest and endothelium-derived hyperpolarizing factor-mediated hyperpolarization and relaxation in coronary arteries: the effect and mechanism

The Journal of Thoracic and Cardiovascular Surgery
G W HeJ A Yang

Abstract

Depolarizing (hyperkalemic) solutions are widely used to preserve organs for transplantation and for cardiac operations. We previously observed that exposure to hyperkalemia reduced endothelium-dependent, noncyclooxygenase- and non-nitric oxide-mediated relaxation. This study was designed to examine the mechanism of this effect with regard to K channels and the associated membrane potential changes. Porcine coronary artery rings were studied in organ chambers. After incubation of the tissue with 20 or 50 mmol/L doses of potassium for 1 hour, the endothelium-derived hyperpolarizing factor-mediated relaxation in the artery and the membrane hyperpolarization in a single coronary smooth muscle cell were studied. The endothelium-derived hyperpolarizing factor-mediated relaxation induced by substance P, which could be significantly inhibited by the Ca(2+)-activated K channel blocker tetraethylammonium but only to a lesser extent by the adenosine triphosphate-sensitive K channel blocker glibenclamide, was significantly reduced. Substance P-induced hyperpolarization of the membrane potential was also significantly reduced by the hyperkalemic incubation with a significantly elevated resting membrane potential. Depolarizing arrest reduce...Continue Reading

References

Feb 1, 1992·The Annals of Thoracic Surgery·R AebaB P Griffith
Mar 1, 1988·British Journal of Pharmacology·M Feletou, P M Vanhoutte
Aug 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·H SatoJ Vinten-Johansen

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Citations

Dec 15, 2005·Heart, Lung & Circulation·Guo-Wei He
Oct 4, 2000·The Annals of Thoracic Surgery·I KrassóiJ G Papp
Mar 17, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Qin YangGuo-Wei He
Nov 5, 1999·Clinical and Experimental Pharmacology & Physiology·G W He
Dec 24, 1997·Clinical and Experimental Pharmacology & Physiology·G W He
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·G W He
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jian-Guo HanGuo-Wei He
Apr 25, 2006·The Annals of Thoracic Surgery·Ying-Ying DongGuo-Wei He
Feb 16, 2002·The Annals of Thoracic Surgery·Alessandro ParolariPaolo Biglioli
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Louis P PerraultPaul M Vanhoutte
Jun 4, 2021·Journal of Pharmacological and Toxicological Methods·Ziva ArimuraYusheng Qu
Jun 25, 2021·World Journal of Transplantation·Jagmeet SinghSandesh Parajuli

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