Depolarizing effects of glycyrrhizin-derivatives relating to the blend effects with paeoniflorin in mouse diaphragm muscle

Japanese Journal of Pharmacology
M KimuraS Shibata

Abstract

Glycyrrhizin (GLR) and its newly synthesized derivatives, deoxoglycyrrhetol dihemisuccinate (I), deoxoglycyrrhetol dihemiphthalate (II), and the related compounds, carbenoxolone and glycyrrhetinic acid hemiphthalate (III), were assayed with or without paeoniflorin (PF) in mice diaphragm muscles. GLR-derivatives per se blocked the nerve-stimulated twitch tensions with the following order of potencies: carbenoxolone = III greater than II = I greater than GLR. The potencies paralleled the extent of muscle depolarization except in the case of I. GLR and I only increased muscle conductance. The blocking effects by GLR-derivatives per se on twitch responses are, therefore, can be explained by depolarization of muscle membranes and not by membrane conductance change. When carbenoxolone, II or GLR were blended with PF, the potentiation of the blocking effects observed may be related to the muscle depolarization rather than by the increase in membrane conductance.

Citations

Jun 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·In Deok Kim, Bae Jin Ha
Dec 2, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yong-Ge GuanZi-Ren Su
Apr 13, 2002·Japanese Journal of Pharmacology·Lih-Chi ChenLing-Ling Yang
Sep 8, 2004·Journal of Cellular Biochemistry·Hideo TsuboiIzumi Nakashima
Jul 8, 2010·Archives of Pharmacal Research·In Deok Kim, Bae Jin Ha
Apr 6, 2006·Chemical & Pharmaceutical Bulletin·Xing-Gang YangWei-San Pan
Jan 12, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·L C ChenL L Yang
Dec 27, 2005·Journal of Pharmaceutical and Biomedical Analysis·Xing-Gang YangWei-San Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.