Depolymerization-Induced Electrochemiluminescence of Insoluble Porphyrin in Aqueous Phase.

Analytical Chemistry
Yanxia WuXiaoquan Lu

Abstract

Exploring efficient and robust electrochemiluminescence (ECL) performance of liposoluble porphyrins in aqueous phase for analytical purposes especially for important biological targets is still very challenging. In this work, a novel depolymerization-induced electrochemiluminescence (DIECL) of porphyrin and β-cyclodextrin (β-CD) self-assembly through a coreactant route was discovered. Among the studied meso-tetrasubstituted porphyrins, self-assembly of 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (THPP) and β-CD (THPP@β-CD) exhibits the best DIECL behavior with high efficiency (21.8%) as well as good reproducibility and stability. A mechanistic study suggests that the facile complexation of porphyrins with amphiphilic β-CD via hydrogen bonding interaction greatly improves the water insolubility and the aggregation-caused deficient ECL of liposoluble porphyrins in aqueous solution. Furthermore, because of the strong hydrogen bonding between the hydroxyl groups on THPP@β-CD and a highly electronegative substrate, such THPP@β-CD is found to serve as an efficient luminophore for recognition of most electronegative fluoride (F-) in the aqueous phase with high sensitivity and selectivity, together with a low limit of detection (0.7...Continue Reading

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