Deposition and phagocytosis of inhaled particles in the gas exchange region of the duck, Anas platyrhynchos

Respiration Physiology
R C StearnsJ D Brain

Abstract

Little is known about the fate of inhaled aerosol particles in birds; even the anatomical location of phagocytic cells within the lungs has yet to be clearly demonstrated. We exposed 2 anesthetized, spontaneously breathing ducks to a non-toxic iron oxide aerosol (aerodynamic mass mean diameter = 0.18 micron; 460 mg/m3) for 1.75 h and 2 awake, resting ducks to less concentrated aerosol (38 mg/m3) for 6 h on two consecutive days. All 4 ducks were sacrificed 24 h after the end of the last exposure. Their lungs, as well as the lungs from a control duck not exposed to the aerosol, were fixed in situ by insufflation of osmium tetroxide vapor or by intravascular perfusion. Then samples of the gas exchange region were examined with a transmission electron microscope. We found iron oxide particles: trapped within the trilaminar substance that is unique to avian lungs and coats the atria and infundibula; within epithelial cells of the atria and initial portions of the infundibula; and within interstitial macrophages. Only occasionally, small amounts of particles were found in the air capillaries. We conclude that both epithelial cells and interstitial macrophages can phagocytize particles in avian lungs, and that there is some convective...Continue Reading

References

Jul 1, 1979·Respiration Physiology·P Bouverot, P Sébert
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Mar 1, 1972·Respiration Physiology·H R Duncker
Dec 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A J SouflerisT G Pretlow
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Citations

Apr 1, 1994·Veterinary Immunology and Immunopathology·J A FagerlandL H Arp
Nov 24, 2006·Avian Pathology : Journal of the W.V.P.A·E A CorbanieC Vervaet
Jun 1, 2014·Veterinary Microbiology·Haitham GhunaimSubhashinie Kariyawasam
May 14, 2014·Avian Pathology : Journal of the W.V.P.A·G KallapuraG Tellez
Jun 17, 2016·Biological Research·Mbuvi P MutuaMuita M Gicheru
Jul 20, 2017·Environmental Toxicology and Chemistry·Mark D JankowskiErik K Hofmeister
Apr 14, 2006·Veterinary Research·Sven ReeseBernd Kaspers

Related Concepts

Ferric oxide monohydrate
Metazoa
Ducks
Ferric Compounds
Fixatives
Histological Techniques
Lung
Phagocytosis
Pulmonary Gas Exchange
Respiration

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