Deposition and phagocytosis of inhaled particles in the gas exchange region of the duck, Anas platyrhynchos

Respiration Physiology
R C StearnsJ D Brain


Little is known about the fate of inhaled aerosol particles in birds; even the anatomical location of phagocytic cells within the lungs has yet to be clearly demonstrated. We exposed 2 anesthetized, spontaneously breathing ducks to a non-toxic iron oxide aerosol (aerodynamic mass mean diameter = 0.18 micron; 460 mg/m3) for 1.75 h and 2 awake, resting ducks to less concentrated aerosol (38 mg/m3) for 6 h on two consecutive days. All 4 ducks were sacrificed 24 h after the end of the last exposure. Their lungs, as well as the lungs from a control duck not exposed to the aerosol, were fixed in situ by insufflation of osmium tetroxide vapor or by intravascular perfusion. Then samples of the gas exchange region were examined with a transmission electron microscope. We found iron oxide particles: trapped within the trilaminar substance that is unique to avian lungs and coats the atria and infundibula; within epithelial cells of the atria and initial portions of the infundibula; and within interstitial macrophages. Only occasionally, small amounts of particles were found in the air capillaries. We conclude that both epithelial cells and interstitial macrophages can phagocytize particles in avian lungs, and that there is some convective...Continue Reading


Jul 1, 1979·Respiration Physiology·P Bouverot, P Sébert
Mar 1, 1975·The Anatomical Record·S P Sorokin, J D Brain
Mar 1, 1972·Respiration Physiology·H R Duncker
Dec 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A J SouflerisT G Pretlow
Jun 1, 1982·The American Journal of Anatomy·Kent E PinkertonJ D Crapo
Dec 1, 1980·Poultry Science·O J Fletcher


Apr 1, 1994·Veterinary Immunology and Immunopathology·J A FagerlandL H Arp
Nov 24, 2006·Avian Pathology : Journal of the W.V.P.A·E A CorbanieC Vervaet
Jun 1, 2014·Veterinary Microbiology·Haitham GhunaimSubhashinie Kariyawasam
May 14, 2014·Avian Pathology : Journal of the W.V.P.A·G KallapuraG Tellez
Jun 17, 2016·Biological Research·Mbuvi P MutuaMuita M Gicheru
Jul 20, 2017·Environmental Toxicology and Chemistry·Mark D JankowskiErik K Hofmeister
Apr 14, 2006·Veterinary Research·Sven ReeseBernd Kaspers

Related Concepts

Ferric oxide monohydrate
Ferric Compounds
Histological Techniques
Pulmonary Gas Exchange

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.