Deposition of catechol-functionalized chitosan and silver nanoparticles on biomedical titanium surfaces for antibacterial application

Materials Science & Engineering. C, Materials for Biological Applications
Yan Fang ChengLi Qun Xu

Abstract

The titanium (Ti) and its alloys have been widely used for dental and orthopedic implants. However, the Ti-based implants may suffer from bacterial infection, which would result in insufficient healing, implant failure and repeated surgical intervention. It is of great interest to inhibit the bacterial adhesion and colonization on the Ti-based implants by introducing proper surface coatings. In this work, a simple method was employed to synthesize the water-soluble catechol-containing chitosan (CACS). The CACS coatings can be deposited onto various substrate surfaces and exhibit substrate-independent behavior. The CACS-coated Ti surfaces were further deposited with silver nanoparticles (Ag NPs) via in-situ reduction of Ag+ ions using catechol moieties as the reducing agents. The resulting AgNPs/CACS-coated Ti surfaces exhibit antibacterial properties and can prevent the surface adhesion of bacterial cells, as evidenced by the inhibition zone test, live/dead bacterial staining assay and spread plate method. In addition, they show negligible cytotoxicity to L929 mouse fibroblast cells.

Citations

May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaofan ZhaiBaorong Hou
Nov 27, 2020·Nanomaterials·Oana GherasimAlexandru Mihai Grumezescu
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jianqiao LiuYujin Tang
Jan 27, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seyedehfatemeh RazaviamriBruce P Lee
Mar 18, 2020·The Journal of Prosthetic Dentistry·Juliana Dias Corpa TardelliAndréa Cândido Dos Reis
Apr 27, 2021·ACS Applied Materials & Interfaces·Xiaodong HeLiqun Xu
May 14, 2021·International Journal of Biological Macromolecules·Jon Andrade Del OlmoJosé Maria Alonso
Oct 14, 2019·ACS Biomaterials Science & Engineering·Fiorela GhiliniCarolina Diaz
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sebastián Mina-AponzáFranklin Bermeo-Acosta
Nov 2, 2021·Journal of Biomaterials Applications·Youbin LiJun Fei

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