PMID: 3761026Sep 1, 1986Paper

Deposition of dietary organic and inorganic selenium in rat erythrocyte proteins

The Journal of Nutrition
M A Beilstein, P D Whanger

Abstract

The deposition of selenium (Se) in erythrocyte proteins was studied in rats fed Se as sodium selenite, selenocystine, selenomethionine (Se-Met), high Se wheat or selenium-enriched yeast. Ion-exchange chromatography of acid hydrolyzates of selenium-enriched yeast, high Se wheat and intrinsically labeled 75Se wheat indicated that the majority of the Se was present as Se-Met. Gel filtration (Sephadex G-150) of erythrocyte lysates revealed that Se was deposited mainly in two proteins, glutathione peroxidase (GPx) and hemoglobin (Hb). When selenite or selenocystine was the dietary form of Se, the majority of the erythrocyte Se was present with GPx, but when the Se was supplied from either Se-Met, yeast or wheat, it was deposited to a greater extent in Hb than GPx. Injection of 75Se as either Se-Met or selenite gave results consistent with the feeding studies. 75Se-labeled selenite injection resulted in labeling of primarily GPx, but 75Se-Met injection labeled predominantly Hb. Hence, the dietary forms of Se influence the relative distribution of Se between GPx and Hb in erythrocytes, and this may be a factor contributing to the difference between human and animal erythrocytes.

Citations

Jun 21, 2002·Journal of the American College of Nutrition·P D Whanger
Jun 16, 2006·Journal of Animal Science·S M RichardsonT L Ward
Apr 1, 1997·The British Journal of Nutrition·M F RobinsonP D Whanger
Mar 27, 1999·FEBS Letters·G E ArteelH Sies
Sep 5, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jan-Ying YehPhilip D Whanger
Oct 27, 2017·International Journal of Molecular Sciences·Bozena HosnedlovaRene Kizek
Apr 1, 1989·Biological Trace Element Research·W B DavidsonC H McMurray
Jan 1, 1988·Biological Trace Element Research·O Thorlacius-Ussing, F T Jensen
Jan 1, 1988·Biological Trace Element Research·A MasB Sarkar
Apr 23, 2002·Journal of Applied Microbiology·C A Ponce de LeónJ A Caruso
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ann L BaldwinAbdu I Alayash
Mar 31, 2000·Free Radical Research·A AssmannK D Asmus
Sep 16, 2008·Journal of Animal Science·L CalamariG Bertin
Aug 1, 1992·Journal of Inorganic Biochemistry·S C VendelandP D Whanger
Jan 28, 2010·Journal of Agricultural and Food Chemistry·Francesco CubaddaNagaraja Tejo Prakash
Dec 1, 1994·Applied and Environmental Microbiology·E TschursinK Y Patterson

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