Deposition of differently sized airborne microspheres in the respiratory tract of chickens

Avian Pathology : Journal of the W.V.P.A
E A CorbanieC Vervaet

Abstract

As a part of the development of an efficient dry powder aerosol vaccine for poultry, the objective of this study was to accurately determine the deposition pattern of nebulized microspheres in the airways of unanaesthetized chickens of different ages (1 day, 2 weeks and 4 weeks old). In the first part of the study, the aerosol administration method was characterized: the influence of different nebulizers and nebulizing protocols on the relative humidity in the exposure chamber, the particle size distributions, the microsphere output and single microsphere percentage were determined. In the second part, birds were exposed to nebulized fluorescently labelled polystyrene microspheres (1 to 20 microm). Respiratory and gastro-intestinal tract tissue samples were collected and the number of fluorescent microspheres per sample was determined. In 2-week-old and 4-week-old chickens, microspheres of 5 and 10 microm, respectively, were too large for deposition in the lungs and air sacs as less than 5% of these microspheres penetrated into the lower airways. The larger size of microspheres reaching the lower airways of 4-week-old birds was explained by increasing airway dimensions with age. For 1-day-old chickens, deposition in the lungs d...Continue Reading

References

Jun 1, 1976·British Journal of Haematology·D L Williams, G H Spray
Feb 1, 1992·Electroencephalography and Clinical Neurophysiology·P J AllenS J Smith
Oct 27, 1973·The Veterinary Record·R E Gough, W H Allan
Jul 1, 1974·Poultry Science·R B Hayter, E L Besch
Dec 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Mensah, J D Brain
Oct 1, 1994·Cardiovascular Research·F W Prinzen, R W Glenny
May 1, 1993·Journal of Applied Physiology·R W GlennyM Brinkley
Mar 1, 1997·Journal of Applied Physiology·H T RobertsonD Covert
Jul 28, 2004·Avian Pathology : Journal of the W.V.P.A·W J M LandmanJo H H van Eck
Jul 1, 1978·Avian Pathology : Journal of the W.V.P.A·H Yadin, F W Orthel

Citations

Mar 26, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Simon ThierryPascal Arné
Nov 20, 2012·Journal of Avian Medicine and Surgery·Lee C EmeryMarcy J Souza
Feb 15, 2011·Avian Diseases·J L PurswellJ D Davis
Oct 20, 2015·Animals : an Open Access Journal From MDPI·Bruce DavidCecilie Mejdell
Aug 10, 2011·International Journal of Microbiology·Pascal ArnéJacques Guillot
Jun 21, 2011·Veterinary Immunology and Immunopathology·Eveline D de GeusLonneke Vervelde
Dec 14, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K HuygeC Vervaet
Mar 10, 2015·Avian Pathology : Journal of the W.V.P.A·Eveline D de GeusLonneke Vervelde
Apr 2, 2013·Developmental and Comparative Immunology·Eveline D de Geus, Lonneke Vervelde
Jun 24, 2017·Drug Delivery and Translational Research·Daniella Calderon-NievaMarianna Foldvari
Jul 18, 2017·Viral Immunology·Mohamed Sarjoon Abdul-CaderMohamed Faizal Abdul-Careem
Apr 16, 2014·Critical Reviews in Environmental Science and Technology·Yang ZhaoPeter W G Groot Koerkamp
Apr 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eveline D de GeusLonneke Vervelde
Apr 4, 2021·Journal of Fungi·Pascal ArnéJacques Guillot
Mar 14, 2020·Journal of Microbiological Methods·Spencer A LeighStephanie D Collier

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Aerosol Dose Form
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