Deposition of lipopigment--a new feature of human splenic sinus endothelium (SSE). Ultrastructural and histochemical study

Virchows Archiv. A, Pathological Anatomy and Histopathology
M Elleder


Lipopigment (LP) deposition was studied in a series of 36 control and 79 pathological spleens. In the control group the LP deposition in SSE was rudimentary and did not display age-dependence. A varying degree of lysosomal and cytoplasmic siderosis was a frequent finding in haemolytic anemia without any significant LP induction. In the acquired secondary storage syndrome and in some inherited lysosomal enzymopathies, the amount of LP in splenic sinus endothelium (SSE) was significantly increased and in some instances its deposition reached very high values. As deposition was not accompanied by any detectable lysosomal lipid storage phenomenon in pulpar histiocytes, the pigmentogenesis is thought to be by a process resembling that for lipofuscin. In ceroid-lipofuscinosis group the SSE affection was of low degree, as seen in other viscera. The LP deposition seems thus to be a prominent, albeit variable feature of human SSE lysosomal pathology and may represent a monotonous response to various stimuli connected with increased demands on the SSE lysosomal system. Only in some lysosomal enzymopathies, typically in sphingomyelinase deficiency was SSE LP deposited progressively and concurrently with the stored lipid. LP deposition was...Continue Reading


Dec 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Elleder
Dec 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M Elleder
Sep 1, 1989·Pathology, Research and Practice·M Elleder
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·L J Zwi, I A Lampert
Jan 1, 1986·Acta Neuropathologica·J W Boellaard, W Schlote
Jul 1, 1985·The Biochemical Journal·B SmedsrødH Pertoft
Feb 1, 1973·American Journal of Clinical Pathology·J C Sieracki, E R Fisher
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·H J Stutte
Jan 1, 1984·Acta Neuropathologica·J J MartinC Ceuterick
Feb 1, 1983·Human Pathology·A Lasser
Dec 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J AlroyM E Pereira
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·M EllederJ Cihula
Jun 10, 1961·Nature·R F DORFMAN
Apr 1, 1965·Experimental and Molecular Pathology·R S COTRAN
Jan 24, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L Florey


Mar 1, 1998·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·I JorisG Majno
Feb 4, 2006·Neurobiology of Aging·Sabrina S Seehafer, David A Pearce

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