Deposition of monodisperse particles in hollow models representing adult and child-size tracheobronchial airways

Health Physics
Michael J OldhamR F Phalen

Abstract

A series of experiments was performed to determine deposition efficiencies of four sizes of radiolabeled monodisperse particles in custom-made hollow tracheobronchial models. The particles had geometric diameters of about 1, 5, 10, and 15 microm. The tracheobronchial models, consisting of a trachea and two or more additional generations, had dimensions representative of a typical adult, a 7-y-old child, and a 4-y-old child; the child-size models were appropriately scaled-down replicas of the adult-size model. Each deposition experiment was conducted using a steady inspiratory airflow representative of low physical activity for the appropriate age of individual: 20 L min(-1) for the adult; 9 L min(-1) for the 7-y-old; 5.5 L min(-1) for the 4-y-old. The results indicate that deposition efficiency of the particles increased substantially (up to 35 times) in all three models as particle diameter increased from 1-15 microm, undoubtedly as a result of particle impaction and sedimentation-related phenomena. An analysis of variance demonstrated the occurrence of statistically-significant (p < 0.05) main effects of hollow model size and particle size; the interaction between the two parameters was also significant. In general, depositio...Continue Reading

Citations

May 20, 2005·Journal of Toxicology and Environmental Health. Part a·Gary L GinsbergMichael P Firestone
Sep 27, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Kristin K Isaacs, Ted B Martonen
Jun 16, 2006·Inhalation Toxicology·Michael J Oldham
Aug 5, 2008·Respiratory Physiology & Neurobiology·Clement KleinstreuerZheng Li
Mar 15, 2006·Journal of Biomechanics·P Worth Longest, Samir Vinchurkar
Sep 28, 2005·Regulatory Toxicology and Pharmacology : RTP·James F CollinsGeorge V Alexeeff
Apr 7, 2017·Environmental Science and Pollution Research International·Maurizio ManigrassoPasquale Avino
Jul 3, 2021·International Journal of Environmental Research and Public Health·Mohammad S IslamGunther Paul

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