Depot differences in steroid receptor expression in adipose tissue: possible role of the local steroid milieu

American Journal of Physiology. Endocrinology and Metabolism
Sergio Rodriguez-CuencaPilar Roca

Abstract

Sex hormones play an important role in adipose tissue metabolism by activating specific receptors that alter several steps of the lipolytic and lipogenic signal cascade in depot- and sex-dependent manners. However, studies focusing on steroid receptor status in adipose tissue are scarce. In the present study, we analyzed steroid content [testosterone (T), 17beta-estradiol (17beta-E2), and progesterone (P4)] and steroid receptor mRNA levels in different rat adipose tissue depots. As expected, T levels were higher in males than in females (P = 0.031), whereas the reverse trend was observed for P4 (P < 0.001). It is noteworthy that 17beta-E2 adipose tissue levels were higher in inguinal than in the rest of adipose tissues for both sexes, where no sex differences in 17beta-E2 tissue levels were noted (P = 0.010 for retroperitoneal, P = 0.005 for gonadal, P = 0.018 for mesenteric). Regarding steroid receptor levels, androgen (AR) and estrogen receptor (ER)alpha and ERbeta densities were more clearly dependent on adipose depot location than on sex, with visceral depots showing overall higher mRNA densities than their subcutaneous counterparts. Besides, expression of ERalpha predominated over ERbeta expression, and progesterone recept...Continue Reading

References

May 1, 1979·Endocrinology·J M Gray, G N Wade
May 1, 1990·Endocrine Reviews·M A Carson-JuricaB W O'Malley
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J P DeslypereA Vermeulen
Feb 1, 1984·Journal of Steroid Biochemistry·A A van LandeghemJ H Thijssen
Aug 1, 1981·The Journal of Endocrinology·D ShirlingJ D Baird
Apr 1, 1994·The Journal of Clinical Endocrinology and Metabolism·T MizutaniA Miyake
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y GiudicelliR Pecquery
Nov 22, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V Van HarmelenP Arner
Jun 5, 1998·The American Journal of Physiology·M N DieudonneY Giudicelli
Jun 5, 1998·The American Journal of Physiology·M DiGirolamoR Rossmanith
Jun 10, 1998·Steroids·J SzymczakJ Daroszewski
Aug 15, 1998·Biochemical and Biophysical Research Communications·D L CrandallJ G Kral
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·E SimpsonS Davis
Aug 5, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P G McTernanS Kumar
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·P A HeineP S Cooke
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·V Serazin-LeroyY Giudicelli
Nov 30, 2000·Biochemical and Biophysical Research Communications·C OhlssonJ A Gustafsson
May 18, 2001·Biochemical Society Transactions·P Arner
Aug 4, 2001·Pflügers Archiv : European journal of physiology·E RodríguezA Palou
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·L A AndersonS Kumar
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Philip G McTernanSudhesh Kumar
May 9, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T EspositoB Varriale
May 22, 2002·The Journal of Biological Chemistry·Britta M JacobsenKathryn B Horwitz
Jun 14, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J JoynerD Cameron
Dec 14, 2002·Biochemical and Biophysical Research Communications·Takashi SatoShigeaki Kato
Mar 19, 2003·Critical Reviews in Eukaryotic Gene Expression·Stefan Nilsson, Jan-Ake Gustafsson
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G AtzmonN Barzilai
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C BélangerA Tchernof
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A NaazP S Cooke

❮ Previous
Next ❯

Citations

Sep 8, 2007·Pharmaceutical Research·Honggang WangQingcheng Mao
Nov 6, 2007·The British Journal of Nutrition·Michael L Power, Jay Schulkin
Aug 25, 2012·The British Journal of Nutrition·Christopher P F Marinangeli, Peter J H Jones
Jan 31, 2008·Expert Reviews in Molecular Medicine·Evanthia Diamanti-Kandarakis
Jun 18, 2010·American Journal of Physiology. Cell Physiology·Geniece M LehmannRichard P Phipps
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sergio Rodriguez-CuencaPilar Roca
Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·Alexandra Bargiota, Evanthia Diamanti-Kandarakis
Mar 10, 2007·BMC Pharmacology·Marta SerranoMarià Alemany
May 2, 2012·Endocrinology·Oleg VarlamovCharles T Roberts
Jan 11, 2014·Asian Journal of Andrology·Mark Ng Tang FuiMathis Grossmann
Feb 18, 2015·Journal of Physiology and Biochemistry·Silvia Gamundi-SeguraJose M Arbones-Mainar
Aug 12, 2014·Human Reproduction·Héctor F Escobar-MorrealeManuel Luque-Ramírez
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Raffaella ComitatoFabio Virgili
May 20, 2016·Biology of Sex Differences·Pilar Argente-ArizónJulie A Chowen
Oct 20, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Karine BlouinAndré Tchernof
Jun 10, 2006·Steroids·Chantal BélangerAndré Tchernof
Dec 3, 2015·Current Obesity Reports·Mouna ZerradiAndré Tchernof
Jul 11, 2008·Journal of Cellular Biochemistry·Yu WenKatherine Cianflone
Nov 13, 2013·The Journal of Clinical Endocrinology and Metabolism·Ksenija VelickovicAleksandra Korac
Aug 18, 2006·Cells, Tissues, Organs·Melinda E FernyhoughMichael V Dodson
Jul 17, 2013·International Journal of Molecular Medicine·Un Suk JungJun-Young Hur
Oct 28, 2019·Journal of the American Heart Association·Samar R El KhoudaryMatthew J Budoff
Feb 17, 2005·American Journal of Physiology. Endocrinology and Metabolism·Marta MonjoPilar Roca
Aug 28, 2018·International Journal of Endocrinology·Eduardo Spinedi, Daniel P Cardinali
Dec 30, 2014·Plastic and Reconstructive Surgery·Jessica D BillsKathryn E Davis
Sep 1, 2015·Expert Review of Endocrinology & Metabolism·Manuel MaliqueoNicolás Crisosto
Jun 9, 2020·European Journal of Clinical Investigation·Manuel F LandechoMarta Cuervo
Jul 28, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Saulo Chaves MagalhãesAriclécio Cunha de Oliveira
Sep 27, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Marco Bauzá-ThorbrüggeAna M Proenza
Mar 25, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Pascal PhrakonkhamMarie-Chantal Canivenc-Lavier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.