Depot-medroxyprogesterone acetate (DMPA) and risk of invasive adenocarcinomas and adenosquamous carcinomas of the uterine cervix. WHO Collaborative Study of Neoplasia and Steroid Contraceptives

Contraception
D B Thomas, R M Ray

Abstract

A hospital-based case-control study was conducted in two hospitals in Bangkok, Thailand, and in one hospital each in Chiang Mai, Thailand, Mexico City, Mexico and Nairobi, Kenya. One purpose of this study was to determine whether the long-acting progestational contraceptive, depot-medroxyprogesterone acetate (DMPA), alters risk of invasive cervical carcinomas with adenomatous histological features. Information on prior use of DMPA, screening for cervical cancer, and the suspected risk factors for this disease was ascertained from interviews of 239 women with adenocarcinomas and 85 women with adenosquamous carcinomas, as well of from a large pool of controls, 2534 of whom were matched to the cases included in this report. For selected subsets of these women, a smoking history was also elicited, blood specimens were collected for measurement of antibodies against herpes simplex and cytomegalovirus, and information on sexual behavior was obtained from interviews of their husbands. The relative risk (and 95% confidence interval) of adenomatous cervical carcinomas in women who ever used DMPA was estimated to be 0.75 (0.51, 1.11). No trends in risk were observed with duration of DMPA use, times since first or last use, or age at firs...Continue Reading

References

Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·R HerreroE Gaitan
Mar 1, 1990·International Journal of Epidemiology·L A BrintonW E Rawls
Jun 1, 1990·International Journal of Epidemiology·F ParazziniR Maggi
Aug 1, 1989·American Journal of Epidemiology·D B ThomasJ A Pallet
Dec 1, 1988·International Journal of Epidemiology·M W OberleM G Bonhomme
Sep 15, 1986·International Journal of Cancer. Journal International Du Cancer·L A BrintonR Hoover
Nov 19, 1994·Lancet·G UrsinM C Pike

❮ Previous
Next ❯

Citations

Apr 27, 2002·AWHONN Lifelines·Sandra Mesics
Aug 11, 2011·Archives of Gynecology and Obstetrics·Hakan YetimalarFerit Soylu
Apr 11, 2003·Lancet·Jennifer S SmithValerie Beral
Apr 24, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Amanda BlackAnne Marie Whelan
Apr 24, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Amanda BlackAnne Marie Whelan
Jul 6, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Sarah M R Hardman, Ailsa E Gebbie
Sep 10, 2013·The American Journal of Pathology·Young A YooSang-Hyuk Chung
Nov 20, 2014·Human Reproduction Update·Bansari PatelSam Mesiano
Nov 9, 2004·The Journal of Family Planning and Reproductive Health Care·UNKNOWN Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit
May 2, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C La Vecchia, S Franceschi
Aug 5, 2009·Deutsches Ärzteblatt International·Meike RessingStefanie J Klug

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.