PMID: 9437559Jan 23, 1998Paper

Depot medroxyprogesterone acetate pioneers. A retrospective study at a North Carolina Health Department

Contraception
L S PotterM Betz

Abstract

This article examines the characteristics of the first group of depot medroxyprogesterone acetate (DMPA) acceptors after US Food and Drug Administration (FDA) approval of the method and evaluates their continuation rates and factors associated with discontinuation. This was a population based retrospective study based on 12 months of clinic data for 510 women who began using DMPA in 1993 at a large county health department. Cumulative 12 month life table rates were calculated for the entire group and were then stratified by selected characteristics. The 4, 8, and 12 month continuation rates were 67%, 46%, and 35%, respectively. More than half of these women discontinued because of bleeding and nonbleeding side effects (25% and 28%, respectively). Almost 20% of these women were considered discontinuers because they waited longer than 16 weeks to return for an injection. As measured in this study, continuation rates for this first group of DMPA acceptors were low. The next step is to determine if the characteristics and patterns of use of these "pioneer" acceptors are representative of more recent acceptors, and if lessons learned from this group will lead to higher continuation rates.

Citations

Jan 5, 2002·Contraception·M E BeksinskaJ Smit
Dec 22, 2000·Contraception·P Chotnopparatpattara, S Taneepanichskul
Mar 15, 2000·Contraception·D HubacherD Taylor
Feb 24, 2001·Clinical Obstetrics and Gynecology·A M Kaunitz
May 18, 1999·Journal of Pediatric and Adolescent Gynecology·A ZibnersJ Hayes
Dec 7, 2002·International Journal of Adolescent Medicine and Health·Hatim OmarSandy D'Angelo
Jun 10, 1998·Current Opinion in Obstetrics & Gynecology·M Polaneczky
Dec 15, 2012·Studies in Family Planning·Joy Noel BaumgartnerMario Chen
May 30, 2006·Contraception·Carla Picardo
Jun 23, 2005·Journal of Pediatric and Adolescent Gynecology·Barbara Cromer
Nov 25, 2000·Obstetrics and Gynecology Clinics of North America·A M Kaunitz
Jun 8, 2015·Current Opinion in HIV and AIDS·Julie E MyersCarolyn Westhoff
Jul 5, 2008·American Journal of Obstetrics and Gynecology·Abbey B BerensonMahbubur Rahman
Aug 30, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·R HellerS T Cameron
Feb 16, 2006·CNS Drugs·Avi Ashkenazi, Stephen D Silberstein

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