Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue.

Obesity
Mi-Jeong LeeAnne Hermanowski-Vosatka

Abstract

Our main objective was to compare the regulation of cortisol production within omental (Om) and abdominal subcutaneous (Abd sc) human adipose tissue. Om and Abd sc adipose tissue were obtained at surgery from subjects with a wide range of BMI. Hydroxysteroid dehydrogenase (HSD) activity ((3)H-cortisone and (3)H-cortisol interconversion) and expression were measured before and after organ culture with insulin and/or dexamethasone. Type 1 HSD (HSD1) mRNA and reductase activity were mainly expressed within adipocytes and tightly correlated with adipocyte size within both depots. There was no depot difference in HSD1 expression or reductase activity, while cortisol inactivation and HSD2 mRNA expression (expressed in stromal cells) were higher in Om suggesting higher cortisol turnover in this depot. Culture with insulin decreased HSD reductase activity in both depots. Culture with dexamethasone plus insulin compared to insulin alone increased HSD reductase activity only in the Om depot. This depot-specific increase in reductase activity could not be explained by an alteration in HSD1 mRNA or protein, which was paradoxically decreased. However, in Om only, hexose-6-phosphate dehydrogenase (H6PDH) mRNA levels were increased by culture...Continue Reading

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Citations

Sep 6, 2012·American Journal of Physiology. Endocrinology and Metabolism·Mi-Jeong Lee, Susan K Fried
Dec 30, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mi-Jeong LeeSusan K Fried
Jan 17, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M-J Lee, S K Fried
May 3, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M-J Lee, S K Fried
Mar 4, 2014·Endocrinology and Metabolism Clinics of North America·Eliza B GeerChristoph Buettner
Jun 2, 2012·Metabolism: Clinical and Experimental·Panagiotis AnagnostisDimitri P Mikhailidis
Aug 9, 2011·Molecular and Cellular Endocrinology·Alex Odermatt, Denise V Kratschmar
Mar 9, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Alain VeilleuxAndré Tchernof
Oct 11, 2015·Journal of Physiology and Biochemistry·P MauriègeD Richard
Jul 25, 2009·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takeshi InagakiJuro Sakai
Feb 26, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Karen E ChapmanJonathan R Seckl
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·André TchernofVan Luu-The
Jul 5, 2013·Cell Metabolism·Jean Galitzky, Anne Bouloumié
Mar 10, 2016·European Journal of Endocrinology·Stuart A MorganGareth G Lavery
Mar 22, 2012·Obesity Facts·Marina MichalakiAthanasios G Papavassiliou
Nov 12, 2014·The Journal of Endocrinology·Johanna L BarclayKen K Y Ho
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Mark S Cooper, Paul M Stewart
Jun 30, 2011·American Journal of Physiology. Endocrinology and Metabolism·Marie-Amélie LukaszewskiChristophe Breton
Sep 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Marie-Amélie LukaszewskiChristophe Breton
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Jan 11, 2013·Physiological Reviews·André Tchernof, Jean-Pierre Després
Aug 1, 2013·Hormone Molecular Biology and Clinical Investigation·Christophe Breton

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