PMID: 8948508Nov 1, 1996Paper

Depressed arteriolar responsiveness to norepinephrine in streptozotocin-induced diabetes in the rat

Prostaglandins
T O Myers, E J Messina

Abstract

We examined the contribution of prostaglandins to altered reactivity to norepinephrine in rat cremaster third order arterioles of streptozotocin (STZ) treated rats and age-matched controls. NE was applied topically to the cremaster muscle of pentobarbital (35 mg/kg) anesthetized rats before and during topical administration of indomethacin (IND: 10 micrograms/ml) four and eight weeks after i.v. injection with of 50 mg/kg STZ (STZ-4W; STZ-8W) or vehicle (C-4W; C-8W), and before and during topical administration of 5,8,11,14 eicosatetraynoic acid (ETYA; 20 micrograms/ml) in STZ-8W and C-8W. Plasma glucose was elevated significantly in STZ-treated rats. Blood pressures and resting arteriolar diameters did not differ. However, vasoconstrictor responses to NE were depressed in STZ-4W and to a greater degree in STZ-8W, IND normalized reactivity to the low doses of NE and partially restored reactivity to the higher doses. ETYA enhanced reactivity to all doses of NE to a greater extent than did IND. These data are consistent with a role for locally produced vasomodulatory arachidonic acid metabolites, including prostaglandins, in the decreased reactivity to NE in diabetic rat cremaster muscle arterioles.

References

Jan 1, 1979·Hormone Research·P MasielloE Bergamini
Feb 15, 1979·The New England Journal of Medicine·M SchydlowerP H Patterson
Jul 13, 1970·Biochemical and Biophysical Research Communications·D T DowningM Bachta
Jul 1, 1969·Canadian Journal of Physiology and Pharmacology·M G Viguera, F A Sunahara
Apr 1, 1984·Canadian Journal of Physiology and Pharmacology·S RamanadhamT E Tenner
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Jun 1, 1964·Circulation Research·M J BRODY, R L DIXON

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