PMID: 8957384Dec 1, 1996Paper

Depressed function in remote myocardium after myocardial infarction: influence of orotic acid

The Annals of Thoracic Surgery
A D CochraneF L Rosenfeldt

Abstract

We have previously shown that infarction impairs recovery of global function after subsequent cardioplegic arrest and that therapy with orotic acid improves recovery. The aim of this study was to measure the effect of infarction on regional and global left ventricular function and to determine whether orotic acid exerts a beneficial effect exclusive of the effects of cardioplegia. Acute myocardial infarction was produced in dogs. They then received either orotic acid or placebo (control) orally (n = 12 per group). Fractional radial shortening and systolic wall thickening were measured by two-dimensional echocardiography before and 1 and 3 days after infarction with and without beta-adrenergic blockade, and in 6 dogs up to 9 days after infarction. Global function was measured under anesthesia 4 days after infarction. In control animals, fractional radial shortening in the infarct decreased from 20.6% +/- 5.1% before infarction to 3.0% +/- 2.2% at day 1 and to 1.9% at day 3 (p < 0.01). In the border zone radial shortening declined from 21.9% +/- 3.7% to 11.0% +/- 2.3% at day 1 and 9.3% +/- 2.8% at day 3 (p < 0.05). In the noninfarcted myocardium radial shortening also declined from 27.1% +/- 1.9% before infarction to 18.3% +/- 2....Continue Reading

References

Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C M MunschJ F Williams
Oct 1, 1987·Circulation·K P GallagherA J Buda
Jun 1, 1986·Journal of the American College of Cardiology·L D GillamA E Weyman
Sep 1, 1966·Circulation Research·M N LevyH Zieske
Jun 1, 1981·Circulation Research·L Ceremuzyński
Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·L K von SegesserM I Turina
Aug 1, 1994·The Annals of Thoracic Surgery·T YehA S Wechsler

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Citations

May 16, 2002·Transplantation Proceedings·Yvoty Alves dos Santos SensP Jabur
Sep 2, 1998·Transplantation Proceedings·J M Morales
Sep 29, 1999·Transplantation Proceedings·J M Morales
Oct 1, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F L RosenfeldtO I Pisarenko

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