Depressed immunological defence mechanisms in mice with experimentally induced diabetes.

Infection and Immunity
O SaikiY Yamamura

Abstract

Persistent diabetes mellitus with marked hyperglycemia was induced in mice by the administration of streptozotocin. In these streptozotocin-induced diabetic mice, resistance to tubercle bacillus challenge and primary as well as secondardy humoral immune responses against foreign erythrocytes were markedly depressed. The T-cell function in delayed hypersensitivity to 2,4-dinitro-1-fluorobenzene and bacterial phagocytic activity or peritoneal macrophages were markedly depressed. In contrast, the B-cell function in antibody production against T-independent antigen and the intracellular killing of bacteria in peritoneal macrophages were intact. We concluded that depression of the T-cell function or the phagocytic activity of macrophages or both may be the main immunological defect in these mice.

References

Jun 1, 1975·The Journal of Infectious Diseases·A A MahmoudK S Warren
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A A RossiniG F Cahill
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Mar 25, 1971·The New England Journal of Medicine·A Mowat, J Baum
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

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Citations

Feb 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·C GeislerK Kølendorf
Jun 23, 2007·American Journal of Respiratory Cell and Molecular Biology·Gregory W MartensHardy Kornfeld
Sep 8, 2010·Veterinary Pathology·T SanoI Narama
Sep 10, 2008·Clinical and Experimental Immunology·R RubinsteinM R Wald
Jan 23, 2014·European Journal of Immunology·Nuria Martinez, Hardy Kornfeld
Oct 16, 2013·Infection and Immunity·Chase WattersKendra P Rumbaugh
Aug 25, 2020·BMC Infectious Diseases·Hyeon-Kyoung KooSung-Soon Lee
Oct 4, 2012·Expert Review of Anti-infective Therapy·Christie Y JeonMeghan A Baker
Jan 11, 2007·Scandinavian Journal of Immunology·B LuoC C Anderson
Jul 5, 2011·BMC Medicine·Meghan A BakerMegan B Murray
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Therese VallerskogHardy Kornfeld
Jan 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meghan A BakerMegan B Murray
Mar 3, 2020·Frontiers in Cardiovascular Medicine·Jenny E KanterKarin E Bornfeldt
May 27, 2015·The Journal of Infectious Diseases·Helen McIlleronAndrew Owen
Dec 4, 2003·FEMS Immunology and Medical Microbiology·Zeki YumukVolkan Dundar
May 26, 2017·Immunology·Pavan Kumar Nathella, Subash Babu
Nov 21, 2009·The Lancet Infectious Diseases·Kelly E Dooley, Richard E Chaisson

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