Depressed Mood Modulates Impact of Chronic Rhinosinusitis Symptoms on Quality of Life

The Journal of Allergy and Clinical Immunology. in Practice
Raphael G BanoubAhmad R Sedaghat

Abstract

It is unknown how severity of depressed mood affects the well-recognized relationship between chronic rhinosinusitis (CRS) symptom burden and decreased general health-related quality of life (QOL). The objective of this study was to determine whether depressed mood would affect the relationship between CRS symptom burden and decreased general health-related QOL. For this cross-sectional study, 610 participants with CRS were prospectively recruited. CRS symptom burden was measured with the 22-item Sino-Nasal Outcome Test (SNOT-22). General health-related QOL was measured with the EuroQol 5-dimensional health utility value (EQ-5D HUV) and visual analog scale (EQ-5D VAS). Depressed mood was measured using the Patient Health Questionnaire-2 (PHQ-2). Participants were stratified as having well-controlled CRS symptoms (SNOT-22 < 35) and poorly controlled CRS symptoms (SNOT-22 ≥ 35). Good general health-related QOL was determined as EQ-5D HUV ≥ 0.9 or EQ-5D VAS ≥ 80, in contrast to low general health-related QOL. In participants with well-controlled CRS symptoms, both SNOT-22 and PHQ-2 were significantly and negatively associated with good general health-related QOL (P < .020 in all cases using multivariable regression). In participan...Continue Reading

Citations

Jul 17, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Rehab TalatAhmad R Sedaghat
Oct 4, 2019·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Qasim Husain, Ahmad R Sedaghat
Oct 3, 2020·The Laryngoscope·Madison V EppersonAhmad R Sedaghat
Jul 22, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marlene M SpethAhmad R Sedaghat
Jan 1, 2019·International Forum of Allergy & Rhinology·Katie M PhillipsAhmad R Sedaghat
Jan 2, 2019·Laryngoscope Investigative Otolaryngology·Ahmad R SedaghatStacey T Gray
Nov 10, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Katie M Phillips, Ahmad R Sedaghat
Nov 27, 2021·American Journal of Rhinology & Allergy·Cheng MaRodney J Schlosser

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