PMID: 7169224Jan 1, 1982Paper

Depressed natural and lectin-dependent cell-mediated cytotoxicity against adherent HEp-2 cells in patients with systemic lupus erythematosus

Immunological Communications
A PerlP Gergely


Natural cell-mediated cytotoxicity /NCMC/ was evaluated using human adherent 3H-thymidine-prelabelled HEp-2 epipharynx carcinoma cells as targets at 50:1 effector-target cell ratio in a 24 hr assay. For lectin-dependent cell-mediated cytotoxicity /LDCC/ studies cultures contained also 25/micrograms/ml concanavalin A /Con A/. Peripheral blood mononuclear cells /PBMC/ of nine patients with active systemic lupus erythematosus /SLE/ failed to exert NCMC or LDCC against HEp-2 targets. In contrast, an increased adherence /decreased detachment from the monolayer/ of HEp-2 target cells was observed in the presence of PBMC from SLE patients that was further promoted by the addition of Con A during LDCC assay.


Jul 1, 1976·The Journal of Clinical Investigation·J L FeldmannN Talal
Aug 1, 1979·The Journal of Clinical Investigation·B CharpentierJ F Bach
Jan 1, 1978·Journal of Immunological Methods·G Huges-LawT H The
Jun 1, 1981·Clinical Immunology and Immunopathology·J KarshC K Osterland
Oct 1, 1981·Scandinavian Journal of Immunology·C L YueY Horiuchi
Jan 1, 1980·Arthritis and Rheumatism·T Hoffman
Apr 1, 1981·Immunology Today·E L Reinherz, S F Schlossman

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