Depressed thymidine kinase activity in zinc-deficient rat embryos.

Proceedings of the Society for Experimental Biology and Medicine
I E Dreosti, L S Hurley

Abstract

The activity of thymidine kinase in 12-day fetuses taken from females exposed to a dietary zinc deficiency during pregnancy was significantly lower than in ad libitum (P less than .05) and restricted-intake (P less than .01) controls. Activity of the enzyme was not restored by in vitro addition of zinc at levels up to 0.075 mM but severe inhibition (approximately 50%) occurred at 0.75 mM. Enzyme activity was also severely reduced (approximately 44%) by 0.017 mM (0.96 mug/ml) of copper which raises the possibility that the reduction in thymidine kinase accompanying zinc deficiency may arise, at least in part, from an absolute or relative change in the intracellular level of copper.

Citations

Jan 1, 1979·American Journal of Hematology·A S Prasad
Jun 1, 1993·Journal of Cellular Physiology·J K ChestersK E Lipson
Apr 23, 2002·Teratology·Janine E Polifka, J M Friedman
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·Y KanemaruT Nakamoto
Jun 1, 1979·Biological Trace Element Research·D H Petering, L A Saryan
Mar 1, 1985·Biological Trace Element Research·I E DreostiS J Manuel
Feb 1, 1979·Environmental Health Perspectives·G P Samarawickrama, M Webb
Oct 1, 1989·Experimental Cell Research·J K ChestersH Vint
Jul 1, 1996·The Journal of Laboratory and Clinical Medicine·A S PrasadG Kumar
May 1, 1991·Early Human Development·Y H NeggersJ M Roseman
Nov 17, 1977·The New England Journal of Medicine·M J PattersonG H Mayor
Sep 1, 1977·CRC Critical Reviews in Clinical Laboratory Sciences·A S Prasad
Dec 6, 2012·Metallomics : Integrated Biometal Science·Reagan McRaeChristoph J Fahrni
Jan 1, 1985·Journal of the American College of Nutrition·A S Prasad
Apr 1, 1996·Journal of the American College of Nutrition·A S Prasad
Jun 1, 1996·Zeitschrift für Ernährungswissenschaft·G RimbachK Krämer
Feb 1, 1981·Journal of Human Nutrition·E J Underwood
Mar 1, 1979·The American Journal of Physiology·A S PrasadJ R Ryan
Jan 1, 1980·The American Journal of Physiology·P B Mutch, L S Hurley

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