Depression affects adherence measurement but not the effectiveness of an adherence intervention in heart failure patients

Journal of the American Pharmacists Association : JAPhA
Richard A HansenMichael D Murray

Abstract

To assess the influence of depressive symptoms on adherence with heart failure medications and to determine whether the effect of a pharmacy-based intervention to improve heart failure medication adherence is modified by depressive symptoms. Secondary analysis of data from a randomized controlled trial. University-affiliated ambulatory care practice. Patients 50 years or older with congestive heart failure randomly assigned to usual care (n = 192) or intervention (n = 122). Pharmacist-provided intervention to improve heart failure medication adherence. Medication adherence was measured via patient self-report and using electronic prescription lids; depressive symptoms were measured using the Geriatric Depression Scale. General linear models examined the main effect of depressive symptoms on medication adherence and whether depressive symptoms modified the effectiveness of the intervention. At baseline, 37% (n = 117) of participants screened positive for depression. In the usual care group, mean adjusted self-reported adherence was 75% for depressed participants and 81% for nondepressed participants (P = 0.04); mean adjusted adherence measured electronically was 71% for depressed participants and 69% for nondepressed participant...Continue Reading

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Citations

Apr 20, 2011·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jeffrey S GonzalezSteven A Safren
May 11, 2013·Current Heart Failure Reports·Jos WiddershovenNina Kupper
Feb 15, 2016·JACC. Heart Failure·Dionne KessingNina Kupper
Apr 4, 2013·Clinical Nursing Research·Hsin-Yi Jean TangBarbara Riegel
Aug 24, 2013·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Jan CameronDavid R Thompson
Jul 20, 2011·Nature Reviews. Cardiology·Barbara RiegelUNKNOWN Medscape
May 10, 2020·The Cochrane Database of Systematic Reviews·Amanda J CrossJohnson George
Apr 3, 2014·Critical Care Nurse·Deborah W ChapaSue Ann Thomas
Apr 16, 2016·Psychosomatic Medicine·Dionne KessingNina Kupper
May 20, 2021·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Esther Calero-MolinaJosep Comin-Colet

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