Depression and anxiety before and after temporal lobe epilepsy surgery

Seizure : the Journal of the British Epilepsy Association
Markus ReuberChristoph Helmstaedter

Abstract

To examine the course of depression and anxiety in patients with temporal lobe epilepsy (TLE) treated with epilepsy surgery (and anticonvulsant drugs) or medical means alone. Of 94 TLE patients evaluated for epilepsy surgery, 76 underwent a resective procedure, 18 continued on medical treatment alone. Depression (Beck Depression Inventory (BDI)) and anxiety scores (Self-Rating Anxiety Scale (SRAS)) were examined during presurgical evaluation (T1) and after a mean of 16 months (T2), or 12 months after surgery. Depression and anxiety scores were related to type of intervention, underlying epileptogenic lesion, change of seizure control and anticonvulsant therapy. At T1, depression and anxiety scores were higher in patients with TLE than scores in published normal populations. At T2, depression but not anxiety scores were significantly lower than at T1. Change of depression scores interacted with improvements of seizure control. Evidence of depression and anxiety is commonly found in patients with TLE. Depression improves not because of epilepsy surgery per se, but because of improved seizure control. This is more commonly achieved by surgery than medical treatment. The results are consistent with the hypothesis that depression in...Continue Reading

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Citations

Oct 12, 2005·Current Psychiatry Reports·Richard M SobelSteven Mandel
Jun 11, 2011·Epidemiology and Psychiatric Sciences·V BarbieriO Gambini
Aug 23, 2008·Epilepsia·Silvia B BonelliJohn S Duncan
Mar 24, 2011·Epilepsia·Sophia MacrodimitrisNathalie Jetté
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Aug 14, 2012·Epilepsia·Christoph Helmstaedter, Juri-Alexander Witt
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Oct 19, 2004·Lancet Neurology·Christian E ElgerMartin Kurthen
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